Hypoxia is an integral component of the tumor microenvironment. Either as chronic or
cycling hypoxia, it exerts a similar effect on cancer processes by activating hypoxia-inducible …

The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Neutrophil extracellular traps (NETs) are part of the innate immune response to infections.
NETs are a meshwork of DNA fibers comprising histones and antimicrobial proteins …

Infection, cancer and cardiovascular diseases are the major causes for morbidity and
mortality in the United States according to the Center for Disease Control. The underlying …

The susceptibility of the brain to ischaemic injury dramatically limits its viability following
interruptions in blood flow. However, data from studies of dissociated cells, tissue …

The aggressive nature of metastatic human cancer has been shown to be related to
numerous abnormalities in growth factors and their receptors. These perturbations confer a …

Pathogenic bacteria that penetrate the intestinal epithelial barrier stimulate an inflammatory
response in the adjacent intestinal mucosa. The present studies asked whether colon …

This review focuses on the molecular stratagems utilized by bacteria, yeast, and mammals in
their adaptation to hypoxia. Among this broad range of organisms, changes in oxygen …

Hypoxia is one of the most common and severe challenges to the maintenance of
homeostasis. Oxygen sensing is a property of all tissues, and the response to hypoxia is …

Hypoxic pulmonary vasoconstriction is associated with but may not be sufficient for the
development of high-altitude pulmonary oedema (HAPO). Hypoxia is known to induce an …