298 Hypertension August 2016 drug adherence. Assessment of adherence is not part of
routine clinical practice and is seldom performed in studies, even those testing drugs or …

Primary aldosteronism (PA), a common, albeit markedly underdiagnosed cause of curable
arterial hypertension, is characterized by plasma levels of aldosterone that are inappropriate …

Adrenal venous sampling is recommended by current guidelines to identify surgically
curable causes of hyperaldosteronism but remains markedly underused. Key factors …

At least 5% of individuals with hypertension have adrenal aldosterone-producing adenomas
(APAs). Gain-of-function mutations in KCNJ5 and apparent loss-of-function mutations in …

Primary aldosteronism (PA), a common cause of high blood pressure (BP), induces left
ventricular (LV) hypertrophy and an excess rate of cardiovascular events. Whether its …

Context: The accurate distinction between unilateral and bilateral adrenal disease in
patients with primary aldosteronism (PA) guides surgical management. Adrenal venous …

Context: Identification of unilateral aldosterone-producing (Conn's) adenomas has
traditionally required lateralization by the invasive and technically difficult procedure of …

Context: Aldosterone-producing adenomas (APA) are heterogeneous. The recent finding of
somatic KCNJ5 mutations suggests a genetic explanation. Objectives: The objectives of this …

Importance In addition to biochemical cure, clinical benefits after surgery for primary
aldosteronism depend on the magnitude of decrease in blood pressure (BP) and use of …

Background Primary aldosteronism is a common but underdiagnosed cause of
hypertension. Patients with this disorder have worse morbidity compared with those with …