The PI3K-Akt-mTOR signaling pathway in human acute myeloid leukemia (AML) cells

I Nepstad, KJ Hatfield, IS Grønningsæter… - International journal of …, 2020 - mdpi.com
Acute myeloid leukemia (AML) is a heterogeneous group of diseases characterized by
uncontrolled proliferation of hematopoietic stem cells in the bone marrow. Malignant cell …

Acute myeloid leukaemia in adult patients: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

M Heuser, Y Ofran, N Boissel, SB Mauri… - Annals of …, 2020 - annalsofoncology.org
Acute myeloid leukaemia (AML) incidence is age dependent, rising markedly in patients
aged! 60 years. Ageing of the European population may therefore contribute to the reported …

How I treat acute myeloid leukemia in the era of new drugs

CD DiNardo, AH Wei - Blood, The Journal of the American …, 2020 - ashpublications.org
The acute myeloid leukemia (AML) treatment landscape has changed substantially since
2017. New targeted drugs have emerged, including venetoclax to target B-cell lymphoma 2 …

Acute myeloid leukemia, version 3.2017, NCCN clinical practice guidelines in oncology

MR O'Donnell, MS Tallman, CN Abboud… - Journal of the National …, 2017 - jnccn.org
Acute myeloid leukemia (AML) is the most common form of acute leukemia among adults
and accounts for the largest number of annual deaths due to leukemias in the United States …

Acute myeloid leukemia

H Döhner, DJ Weisdorf… - New England Journal of …, 2015 - Mass Medical Soc
Acute Myeloid Leukemia | New England Journal of Medicine Skip to main content The New
England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES Cardiology …

[HTML][HTML] The clinical impact of the molecular landscape of acute myeloid leukemia

S Kayser, MJ Levis - Haematologica, 2023 - ncbi.nlm.nih.gov
Research into the underlying pathogenic mechanisms of acute myeloid leukemia (AML) has
led to remarkable advances in our understanding of the disease. Mutations now allow us to …

An update of current treatments for adult acute myeloid leukemia

H Dombret, C Gardin - Blood, The Journal of the American …, 2016 - ashpublications.org
Recent advances in acute myeloid leukemia (AML) biology and its genetic landscape
should ultimately lead to more subset-specific AML therapies, ideally tailored to each …

New directions for emerging therapies in acute myeloid leukemia: the next chapter

N Daver, AH Wei, DA Pollyea, AT Fathi, P Vyas… - Blood cancer …, 2020 - nature.com
Conventional therapy for acute myeloid leukemia is composed of remission induction with
cytarabine-and anthracycline-containing regimens, followed by consolidation therapy …

Acute myeloid leukemia: Treatment and research outlook for 2021 and the MD Anderson approach

HM Kantarjian, TM Kadia, CD DiNardo, MA Welch… - Cancer, 2021 - Wiley Online Library
The unraveling of the pathophysiology of acute myeloid leukemia (AML) has resulted in
rapid translation of the information into clinical practice. After more than 40 years of slow …

Updates on targeted therapies for acute myeloid leukaemia

S Kayser, MJ Levis - British journal of haematology, 2022 - Wiley Online Library
In the past few years research in the underlying pathogenic mechanisms of acute myeloid
leukaemia (AML) has led to remarkable advances in our understanding of the disease …