Gene therapy strategies for glaucoma from IOP reduction to retinal neuroprotection: progress towards non-viral systems

A Hakim, B Guido, L Narsineni, DW Chen… - Advanced drug delivery …, 2023 - Elsevier
Glaucoma is the result of the gradual death of retinal ganglion cells (RGCs) whose axons
form the optic nerve. Elevated intraocular pressure (IOP) is a major risk factors …

[HTML][HTML] Therapeutic drugs and devices for tackling ocular hypertension and glaucoma, and need for neuroprotection and cytoprotective therapies

NA Sharif - Frontiers in pharmacology, 2021 - frontiersin.org
Damage to the optic nerve and the death of associated retinal ganglion cells (RGCs) by
elevated intraocular pressure (IOP), also known as glaucoma, is responsible for visual …

FP and EP2 prostanoid receptor agonist drugs and aqueous humor outflow devices for treating ocular hypertension and glaucoma

NA Sharif, N Odani-Kawabata, F Lu… - Experimental Eye …, 2023 - Elsevier
Prostaglandin (PG) receptors represent important druggable targets due to the many diverse
actions of PGs in the body. From an ocular perspective, the discovery, development, and …

A new biomechanical glaucoma factor to discriminate normal eyes from normal pressure glaucoma eyes

KR Pillunat, R Herber, E Spoerl, C Erb… - Acta …, 2019 - Wiley Online Library
Background To test the ability of the newly calculated Dresden biomechanical glaucoma
factor (DBGF) based on dynamic corneal response (DCR) deformation and corneal …

Recently approved drugs for lowering and controlling intraocular pressure to reduce vision loss in ocular hypertensive and glaucoma patients

NA Sharif - Pharmaceuticals, 2023 - mdpi.com
Serious vision loss occurs in patients affected by chronically raised intraocular pressure
(IOP), a characteristic of many forms of glaucoma where damage to the optic nerve …

Pseudoexfoliative glaucoma, endothelial dysfunction, and arterial stiffness: the role of circulating apoptotic endothelial microparticles

E Bourouki, E Oikonomou, M Moschos… - Journal of …, 2019 - journals.lww.com
Purpose: PExG is characterized by the deposition of pseudoexfoliative material in several
tissues and organs including in the cardiovascular system. This study aimed to evaluate the …

Nailfold capillaroscopy of resting peripheral blood flow in exfoliation glaucoma and primary open-angle glaucoma

S Philip, A Najafi, A Tantraworasin… - JAMA …, 2019 - jamanetwork.com
Importance Systemic blood flow alterations have been described using video nailfold
capillaroscopy (NFC) in high-tension glaucoma (HTG) and normal-tension glaucoma (NTG) …

Integrative evaluation and experimental validation of the immune-modulating potential of dysregulated extracellular matrix genes in high-grade serous ovarian cancer …

Q Wu, X He, J Liu, C Ou, Y Li, X Fu - Cancer Cell International, 2023 - Springer
Background High-grade serous ovarian cancer (HGSOC) is a challenging malignancy
characterized by complex interactions between tumor cells and the surrounding …

[HTML][HTML] Degeneration of retina-brain components and connections in glaucoma: Disease causation and treatment options for eyesight preservation

NA Sharif - Current Research in Neurobiology, 2022 - Elsevier
Eyesight is the most important of our sensory systems for optimal daily activities and overall
survival. Patients who experience visual impairment due to elevated intraocular pressure …

A naturally fluorescent Mgp transgenic mouse for angiogenesis and glaucoma longitudinal studies

P Asokan, RN Mitra, R Periasamy… - … & Visual Science, 2018 - iovs.arvojournals.org
Purpose: Our goal was to generate and characterize a new mouse model in which only
angiogenesis-and glaucoma-relevant tissues would be naturally fluorescent. The Matrix Gla …