Although colorectal cancer (CRC) screening has reduced the incidence of and mortality from
CRC, chemoprevention strategies have the potential to further reduce CRC incidence and …

Background Aspirin has been associated to a reduced risk of colorectal and possibly of a
few other common cancers. Methods To provide an up-to-date quantification of this …

Background Epidemiological studies have clarified the potential associations between
regular aspirin use and cancers. However, it remains controversial on whether aspirin use …

The existing epidemiologic literature was comprehensively reviewed to retrieve all
epidemiologic studies (case control and cohort studies) that examined exposure to …

Cancer cells undergo considerable metabolic changes to foster uncontrolled proliferation in
a hostile environment characterized by nutrient deprivation, poor vascularization and …

Cohesive scientific evidence from molecular, animal, and human investigations supports the
hypothesis that constitutive overexpression of cyclooxygenase-2 (COX-2) is a ubiquitous …

Therapeutic resistance has been and remains to be the major challenge in developing
successful treatments for different cancers and therefore, understanding the underlying …

Background Colorectal cancer can be efficiently treated when found at early stages, thus the
search for novel markers is of paramount importance. Since inflammation is associated with …

Aspirin was commercialized more than a 100 years ago. Today, this compound is still widely
prescribed, and new mechanisms of action and indications are being tested. Inhibition of …

Colorectal cancer (CRC) is characterized by the partial suppression of apoptosis, which in
turn gives tumours a selective advantage for survival and can cause current chemotherapy …