The role of myostatin in muscle wasting: an overview
Y Elkina, S von Haehling, SD Anker… - Journal of cachexia …, 2011 - Springer
Myostatin is an extracellular cytokine mostly expressed in skeletal muscles and known to
play a crucial role in the negative regulation of muscle mass. Upon the binding to activin …
play a crucial role in the negative regulation of muscle mass. Upon the binding to activin …
Molecular mechanism of sarcopenia and cachexia: recent research advances
K Sakuma, W Aoi, A Yamaguchi - Pflügers Archiv-European Journal of …, 2017 - Springer
Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Muscle loss occurs as a consequence of several chronic diseases (cachexia) …
respiration. Muscle loss occurs as a consequence of several chronic diseases (cachexia) …
Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action
Over the last two decades, new insights into the etiology of skeletal muscle wasting/atrophy
under diverse clinical settings including denervation, AIDS, cancer, diabetes, and chronic …
under diverse clinical settings including denervation, AIDS, cancer, diabetes, and chronic …
Stem cell activation in skeletal muscle regeneration
Muscle stem cell (satellite cell) activation post muscle injury is a transient and critical step in
muscle regeneration. It is regulated by physiological cues, signaling molecules, and …
muscle regeneration. It is regulated by physiological cues, signaling molecules, and …
[HTML][HTML] Myostatin (GDF-8) as a key factor linking muscle mass and skeletal form
MN Elkasrawy, MW Hamrick - Journal of musculoskeletal & …, 2010 - ncbi.nlm.nih.gov
Abstract Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-β)
superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads …
superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads …
Muscle–bone interactions: basic and clinical aspects
L Cianferotti, ML Brandi - Endocrine, 2014 - Springer
Muscle and bone are anatomically and functionally closely connected. The traditional
concept that skeletal muscles serve to load bone and transform skeletal segments into a …
concept that skeletal muscles serve to load bone and transform skeletal segments into a …
Effects of spaceflight on murine skeletal muscle gene expression
DL Allen, ER Bandstra, BC Harrison… - Journal of Applied …, 2009 - journals.physiology.org
Spaceflight results in a number of adaptations to skeletal muscle, including atrophy and
shifts toward faster muscle fiber types. To identify changes in gene expression that may …
shifts toward faster muscle fiber types. To identify changes in gene expression that may …
Myostatin inhibition enhances the effects of exercise on performance and metabolic outcomes in aged mice
NK LeBrasseur, TM Schelhorn… - … Series A: Biomedical …, 2009 - academic.oup.com
The objective of this study was to examine the effects of short-term exercise training,
myostatin inhibition (PF-354), and exercise+ PF-354, all relative to a vehicle control, on …
myostatin inhibition (PF-354), and exercise+ PF-354, all relative to a vehicle control, on …
Diabetes, sarcopenia, and frailty
JE Morley - Clinics in geriatric medicine, 2008 - Elsevier
Frailty is a pre-disability condition. It now can be defined clinically. The major factors leading
to frailty are sarcopenia and a decline in executive function. Stressors precipitate frail …
to frailty are sarcopenia and a decline in executive function. Stressors precipitate frail …
Management of cancer cachexia: attempting to develop new pharmacological agents for new effective therapeutic options
GP Marceca, P Londhe, F Calore - Frontiers in oncology, 2020 - frontiersin.org
Cancer cachexia (CC) is a multifactorial syndrome characterized by systemic inflammation,
uncontrolled weight loss and dramatic metabolic alterations. This includes myofibrillar …
uncontrolled weight loss and dramatic metabolic alterations. This includes myofibrillar …