Myostatin is an extracellular cytokine mostly expressed in skeletal muscles and known to
play a crucial role in the negative regulation of muscle mass. Upon the binding to activin …

Skeletal muscle provides a fundamental basis for human function, enabling locomotion and
respiration. Muscle loss occurs as a consequence of several chronic diseases (cachexia) …

Over the last two decades, new insights into the etiology of skeletal muscle wasting/atrophy
under diverse clinical settings including denervation, AIDS, cancer, diabetes, and chronic …

Muscle stem cell (satellite cell) activation post muscle injury is a transient and critical step in
muscle regeneration. It is regulated by physiological cues, signaling molecules, and …

Abstract Myostatin (GDF-8) is a member of the transforming growth factor-beta (TGF-β)
superfamily that is highly expressed in skeletal muscle, and myostatin loss-of-function leads …

Muscle and bone are anatomically and functionally closely connected. The traditional
concept that skeletal muscles serve to load bone and transform skeletal segments into a …

Spaceflight results in a number of adaptations to skeletal muscle, including atrophy and
shifts toward faster muscle fiber types. To identify changes in gene expression that may …

The objective of this study was to examine the effects of short-term exercise training,
myostatin inhibition (PF-354), and exercise+ PF-354, all relative to a vehicle control, on …

Frailty is a pre-disability condition. It now can be defined clinically. The major factors leading
to frailty are sarcopenia and a decline in executive function. Stressors precipitate frail …

Cancer cachexia (CC) is a multifactorial syndrome characterized by systemic inflammation,
uncontrolled weight loss and dramatic metabolic alterations. This includes myofibrillar …