Oxidative stress occurs in a variety of disease settings and is strongly linked to the
development of neuron death and neuronal dysfunction. Cells are equipped with numerous …

Alzheimer's disease (AD) is a progressive neurodegenerative disease that represents the
most common form of dementia among the elderly. Despite the fact that AD was studied for …

Mitochondrial dysfunction is a prominent feature of Alzheimer's disease (AD) and increased
production of reactive oxygen species (ROS) has been described in postmortem brain …

The senescence accelerated mouse (SAMP8) is a spontaneous animal model of
overproduction of amyloid precursor protein (APP) and oxidative damage. It develops early …

The pathology of Alzheimer's disease (AD) is characterized by amyloid plaques (aggregates
of amyloid-β (Aβ)) and neurofibrillary tangles (aggregates of tau) and is accompanied by …

Abstract NAD (P) H quinone oxidoreductase 1 (NQO1) is a multi-functional protein that
catalyses the reduction of quinones (and other molecules), thus playing roles in xenobiotic …

We explore the role of DNA damage processing in the progression of cognitive decline by
creating a new mouse model. The new model is a cross of a common Alzheimer's disease …

The pathomechanism of Alzheimer's disease (AD) certainly involves mitochondrial
disturbances, glutamate excitotoxicity, and neuroinflammation. The three main aspects of …

Neuroinflammation and oxidative stress play key roles in the progression of
neurodegenerative diseases. Thus, the use of potent anti-inflammatory/antioxidant agents …

In this mini-review/opinion article we describe evidence that multiple cellular and molecular
alterations in Alzheimer's disease (AD) pathogenesis involve perturbed cellular calcium …