Factors affecting variation of the human gut phageome
The gut microbiome is a dense and metabolically active consortium of microorganisms and
viruses located in the lower gastrointestinal tract of the human body. Bacteria and their …
viruses located in the lower gastrointestinal tract of the human body. Bacteria and their …
[HTML][HTML] Mutant RAS and the tumor microenvironment as dual therapeutic targets for advanced colorectal cancer
JBE Janssen, JP Medema, EC Gootjes… - Cancer treatment …, 2022 - Elsevier
RAS genes are the most frequently mutated oncogenes in cancer. These mutations occur in
roughly half of the patients with colorectal cancer (CRC). RAS mutant tumors are resistant to …
roughly half of the patients with colorectal cancer (CRC). RAS mutant tumors are resistant to …
[HTML][HTML] Treatment strategies for KRAS-mutated non-small-cell lung cancer
Simple Summary KRAS plays an important role in transmitting signals from growth factors on
the outside of the cell to the cell nucleus. It regulates cell proliferation, growth, and survival …
the outside of the cell to the cell nucleus. It regulates cell proliferation, growth, and survival …
[HTML][HTML] Dichotomous colorectal cancer behaviour
Colorectal cancer (CRC) is the third most common malignant tumor and one of the deadliest
cancers. At molecular level, CRC is a heterogeneous disease that could be divided in four …
cancers. At molecular level, CRC is a heterogeneous disease that could be divided in four …
[HTML][HTML] 3-Bromopyruvate overcomes cetuximab resistance in human colorectal cancer cells by inducing autophagy-dependent ferroptosis
M Mu, Q Zhang, C Zhao, X Li, Z Chen, X Sun… - Cancer Gene …, 2023 - nature.com
Colorectal cancer (CRC) remains a leading cause of cancer-related death worldwide.
Cetuximab, in combination with chemotherapy, is effective for treating patients with wild-type …
Cetuximab, in combination with chemotherapy, is effective for treating patients with wild-type …
Identification of novel peptide inhibitors for oncogenic KRAS G12D as therapeutic options using mutagenesis-based remodeling and MD simulations
The Kirsten rat sarcoma 2 viral oncogene homolog (KRAS) serves as a molecular switch,
cycling between guanosine triphosphate (GTP)-bound and inactive guanosine diphosphate …
cycling between guanosine triphosphate (GTP)-bound and inactive guanosine diphosphate …
[HTML][HTML] Antitumor Efficacy of Dual Blockade with Encorafenib + Cetuximab in Combination with Chemotherapy in Human BRAFV600E-Mutant Colorectal Cancer
S Napolitano, M Woods, HM Lee, V De Falco… - Clinical Cancer …, 2023 - AACR
Abstract Purpose: Encorafenib+ cetuximab (E+ C) is an effective therapeutic option in
chemorefractory BRAF V600E metastatic colorectal cancer (mCRC). However, there is a …
chemorefractory BRAF V600E metastatic colorectal cancer (mCRC). However, there is a …
[HTML][HTML] Recent advances in the study of extracellular vesicles in colorectal cancer
SE Glass, RJ Coffey - Gastroenterology, 2022 - Elsevier
There has been significant progress in the study of extracellular vesicles (EVs) since the
2017 American Gastroenterological Association–sponsored Freston Conference …
2017 American Gastroenterological Association–sponsored Freston Conference …
[HTML][HTML] Cell phenotypes can be predicted from propensities of protein conformations
Proteins exist as dynamic conformational ensembles. Here we suggest that the propensities
of the conformations can be predictors of cell function. The conformational states that the …
of the conformations can be predictors of cell function. The conformational states that the …
[HTML][HTML] Deep learning based radiomics for gastrointestinal cancer diagnosis and treatment: A minireview
PK Wong, IN Chan, HM Yan, S Gao… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Gastrointestinal (GI) cancers are the major cause of cancer-related mortality globally.
Medical imaging is an important auxiliary means for the diagnosis, assessment and …
Medical imaging is an important auxiliary means for the diagnosis, assessment and …