Material design for lymph node drug delivery

A Schudel, DM Francis, SN Thomas - Nature Reviews Materials, 2019 - nature.com
A significant fraction of the total immune cells in the body are located in several hundred
lymph nodes, in which lymphocyte accumulation, activation and proliferation are organized …

From sewer to saviour—targeting the lymphatic system to promote drug exposure and activity

NL Trevaskis, LM Kaminskas, CJH Porter - Nature reviews Drug …, 2015 - nature.com
The lymphatic system serves an integral role in fluid homeostasis, lipid metabolism and
immune control. In cancer, the lymph nodes that drain solid tumours are a primary site of …

Chemistry, biology, and medicine of fluorescent nanomaterials and related systems: new insights into biosensing, bioimaging, genomics, diagnostics, and therapy

J Yao, M Yang, Y Duan - Chemical reviews, 2014 - ACS Publications
2. INTRODUCTION The investigation of many fundamental processes in life sciences
requires straightforward tools for fast, sensitive, reliable, and reproducible detection of …

[HTML][HTML] An update on oral drug delivery via intestinal lymphatic transport

Z Zhang, Y Lu, J Qi, W Wu - Acta Pharmaceutica Sinica B, 2021 - Elsevier
Orally administered drug entities have to survive the harsh gastrointestinal environment,
penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the …

Advanced drug delivery to the lymphatic system: lipid-based nanoformulations

AA Khan, J Mudassir, N Mohtar… - International journal of …, 2013 - Taylor & Francis
The delivery of drugs and bioactive compounds via the lymphatic system is complex and
dependent on the physiological uniqueness of the system. The lymphatic route plays an …

Nanoparticle drug delivery systems designed to improve cancer vaccines and immunotherapy

Y Fan, JJ Moon - Vaccines, 2015 - mdpi.com
Recent studies have demonstrated great therapeutic potential of educating and unleashing
our own immune system for cancer treatment. However, there are still major challenges in …

Self-microemulsifying drug delivery system (SMEDDS)–challenges and road ahead

S Dokania, AK Joshi - Drug delivery, 2015 - Taylor & Francis
Self-microemulsifying drug delivery system (SMEDDS) has emerged as a vital strategy to
formulate poor water soluble compounds for bioavailability enhancement. However, certain …

Development of vaccine formulations: past, present, and future

C D'Amico, F Fontana, R Cheng, HA Santos - Drug Delivery and …, 2021 - Springer
The current situation, heavily influenced by the ongoing pandemic, puts vaccines back into
the spotlight. However, the conventional and traditional vaccines present disadvantages …

Functional roles of magnetic nanoparticles for the identification of metastatic lymph nodes in cancer patients

Y Yan, Y Liu, T Li, Q Liang, A Thakur, K Zhang… - Journal of …, 2023 - Springer
Staging lymph nodes (LN) is crucial in diagnosing and treating cancer metastasis.
Biotechnologies for the specific localization of metastatic lymph nodes (MLNs) have …

Amalgamated Microneedle Array Bearing Ribociclib-Loaded Transfersomes Eradicates Breast Cancer via CD44 Targeting

M Sharma, N Mittapelly, VT Banala, S Urandur… - …, 2022 - ACS Publications
HR+/HER2–metastatic breast cancer (MBC) is one of the most common and life-threatening
conditions diagnosed in women. The endocrine therapy using an orally active CDK4/6 …