Abstract Helix–loop–helix (HLH) proteins are dimeric transcription factors that control
lineage-and developmental-specific gene programs. Genes encoding for HLH proteins …

Congenital heart defects constitute the most common human birth defect, however
understanding of how these disorders originate is limited by our ability to model the human …

Organogenesis involves integration of diverse cell types; dysregulation of cell-type-specific
gene networks results in birth defects, which affect 5% of live births. Congenital heart defects …

The development of single cell RNA sequencing technologies has accelerated the ability of
scientists to understand healthy and disease states of the cardiovascular system. Congenital …

The mammalian heart arises from various populations of Mesp1-expressing cardiovascular
progenitors (CPs) that are specified during the early stages of gastrulation. Mesp1 is a …

Reprogramming non-cardiomyocytes (non-CMs) into cardiomyocyte (CM)-like cells is a
promising strategy for cardiac regeneration in conditions such as ischemic heart disease …

Noradrenergic neuroblastoma is characterized by a core transcriptional regulatory circuitry
(CRC) comprised of transcription factors (TF) such as PHOX2B, HAND2, and GATA3, which …

The cardiac valvular endothelial cells (VECs) are an ideal cell source that could be used for
making the valve organoids. However, few studies have been focused on the derivation of …

Early heart morphogenesis involves a process in which embryonic precursor cells are
instructed to form a cyclic contracting muscle tube connected to blood vessels, pumping …

Abstract Background In 1990, David Barker proposed that prenatal nutrition is directly linked
to adult cardiovascular disease. Since then, the relationship between adult cardiovascular …