Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

Our understanding of the tumor microenvironment (TME), including the interplay between
tumor cells, stromal cells, immune cells, and extracellular matrix components, is mandatory …

Since the" seed and soil" hypothesis was proposed, the biological functions of the tumor
microenvironment (TME), especially its stromal components, have received increasing …

Pancreatic cancer is the 4th leading cause of cancer deaths in the United States. The
pancreatic cancer phenotype is primarily a consequence of oncogenes disturbing the …

Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer. The poor prognosis
calls for a more detailed understanding of disease biology in order to pave the way for the …

Simple Summary There is currently no effective treatment for Pancreatic Ductal
Adenocarcinoma (PDAC), and it is still the deadliest cancer, despite great research efforts in …

It is notorious that cancer cells alter their metabolism to adjust to harsh environments of
hypoxia and nutritional starvation. Metabolic reprogramming most often occurs in the tumor …

During tumor development, invasion and metastasis, the intimate interaction between tumor
and stroma shapes the tumor microenvironment and dictates the fate of tumor cells. Stromal …

Simple Summary The different components surrounding a tumor are collectively known as
the tumor microenvironment (TME). The transforming growth factor-beta (TGF-β) signaling …

Non-small cell lung cancer (NSCLC) constitutes the majority of lung cancer, which is the
leading cause of cancer-related deaths in the world. Nearly 70% of NSCLC patients were …