This review focuses on the mechanisms regulating the synthesis, secretion, biological
actions, and therapeutic relevance of the incretin peptides glucose-dependent insulinotropic …

Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within
minutes after eating. One of their many physiological roles is to regulate the amount of …

G protein coupled receptors (GPCRs) convey signals across membranes via interaction with
G proteins. Originally, an individual GPCR was thought to signal through one G protein …

Peptide hormones within the secretin-glucagon family are expressed in endocrine cells of
the pancreas and gastrointestinal epithelium and in specialized neurons in the brain, and …

Glucagon‐like peptide‐1 (7‐36) amide (GLP‐1) is a 30‐residue peptide hormone released
from intestinal L cells following nutrient consumption. It potentiates the glucose‐induced …

Summary Glucagon-like Peptide 1 (GLP-1)-expressing neurons in the hindbrain send robust
projections to the paraventricular nucleus of the hypothalamus (PVN), which is involved in …

Obesity, diabetes, insulin resistance, sedentary lifestyle, and Western diet are the key factors
underlying non-alcoholic fatty liver disease (NAFLD), one of the most common liver diseases …

Strategies aimed at mimicking or enhancing the action of the incretin hormone glucagon-like
peptide 1 (GLP-1) therapeutically improve glucose-stimulated insulin secretion (GSIS); …

Objective—Endothelial cell senescence is an important contributor to vascular aging and is
increased under diabetic conditions. Here we investigated whether the antidiabetic hormone …

The glucagon-like peptide-1 (GLP-1) receptor is a key regulator of insulin secretion and a
major therapeutic target for treatment of diabetes. However, GLP-1 receptor function is …