We have previously reported 1, 2, 6, 7-tetraoxaspiro [7.11] nonadecane (N-89) as a
promising antimalarial compound. In this study, we evaluated the effect of transdermal …

A series of thiophene-coumarin hybrids (3, 5, 7, and 9) has been produced from the reaction
of various thiocarbamoyl compounds with 3-bromoacetylcoumarin. The DFT/B3LYP …

Sulphonamide motif is found extensively in numerous chemotherapeutic drug candidates, it
acts by stopping the production of folate inside the bacterial cell. Current research has …

The conformational stability of sulfonamide derivatives was examined in the active site of the
Dihydropteroate synthase enzyme. The best-docked conformer was identified via the …

Raltitrexed is a classical antifolate drug with antimetabolite and anticancer properties. In this
research, we provide its detailed antitrypanosomal inhibition against six Trypanosoma …

In light of the growing concern surrounding antimicrobial resistance (AMR), there is an
urgent need for novel antimicrobial agents with enhanced efficacy and reduced …

The growing problem of bacterial resistance to antimicrobials actualizes the development of
new approaches to solve this challenge. Supramolecular chemistry tools can overcome the …

Folates are essential for nucleotide biosynthesis, amino acid metabolism and cellular
proliferation. Following carrier-mediated uptake, folates are polyglutamylated by folylpoly-ɣ …

Sulfonamides are one of the oldest groups of antibacterial agents with a broad-spectrum,
used as first line treatment in bacterial infections. Their widespread use produced a selective …

Peripheral nerve injury (PNI) represents a serious clinical and public health problem due to
its high incurrence and poor spontaneous recovery. Compared to autograft, which is still the …