Stem cell-derived extracellular vesicles as new tools in regenerative medicine-immunomodulatory role and future perspectives

E Karnas, P Dudek, EK Zuba-Surma - Frontiers in immunology, 2023 - frontiersin.org
In the last few decades, the practical use of stem cells (SCs) in the clinic has attracted
significant attention in the regenerative medicine due to the ability of these cells to proliferate …

[HTML][HTML] Different priming strategies improve distinct therapeutic capabilities of mesenchymal stromal/stem cells: Potential implications for their clinical use

V Miceli, G Zito, M Bulati, A Gallo, R Busà… - World Journal of Stem …, 2023 - ncbi.nlm.nih.gov
Mesenchymal stromal/stem cells (MSCs) have shown significant therapeutic potential, and
have therefore been extensively investigated in preclinical studies of regenerative medicine …

The truth is out there: biological features and clinical indications of Extracellular vesicles from human perinatal stem cells

E Russo, G Alberti, S Corrao, CV Borlongan, V Miceli… - Cells, 2023 - mdpi.com
The potential of perinatal tissues to provide cellular populations to be used in different
applications of regenerative medicine is well established. Recently, the efforts of …

3D culture and interferon-γ Priming modulates characteristics of mesenchymal stromal/stem cells by modifying the expression of both intracellular and exosomal …

M Bulati, A Gallo, G Zito, R Busà, G Iannolo, N Cuscino… - Biology, 2023 - mdpi.com
Simple Summary With the aim of improving the therapeutic potential of mesenchymal
stromal/stem cells (MSCs), we analyzed miRNA expression to investigate the effects of …

Role of mesenchymal stem/stromal cells in modulating ischemia/reperfusion injury: current state of the art and future perspectives

V Miceli, M Bulati, A Gallo, G Iannolo, R Busà… - Biomedicines, 2023 - mdpi.com
Ischemia/reperfusion injury (IRI) is a multistep damage that occurs in several tissues when a
blood flow interruption is inevitable, such as during organ surgery or transplantation. It is …

Novel approaches for long-term lung transplant survival

CL Miller, JM O, JS Allan, JC Madsen - Frontiers in Immunology, 2022 - frontiersin.org
Allograft failure remains a major barrier in the field of lung transplantation and results
primarily from acute and chronic rejection. To date, standard-of-care immunosuppressive …

Facing the challenges in the COVID-19 pandemic era: from standard treatments to the umbilical cord-derived mesenchymal stromal cells as a new therapeutic strategy

E Russo, S Corrao, F Di Gaudio, G Alberti, M Caprnda… - Cells, 2023 - mdpi.com
Coronavirus disease 2019 (COVID-19), the pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2), which counts more than 650 million cases and …

Current perspectives on adult mesenchymal stromal cell-derived extracellular vesicles: Biological features and clinical indications

G Alberti, E Russo, S Corrao, R Anzalone, P Kruzliak… - Biomedicines, 2022 - mdpi.com
Extracellular vesicles (EVs) constitute one of the main mechanisms by which cells
communicate with the surrounding tissue or at distance. Vesicle secretion is featured by …

Current status and future potential of ex vivo lung perfusion in clinical lung transplantation

AL Zhou, EL Larson, JM Ruck, JS Ha… - Artificial …, 2023 - Wiley Online Library
Lung transplantation is accepted as a well‐established and effective treatment for patients
with end‐stage lung disease. While the number of candidates added to the waitlist continues …

Mesenchymal stromal cell therapy in lung transplantation

AI Nykänen, M Liu, S Keshavjee - Bioengineering, 2023 - mdpi.com
Lung transplantation is often the only viable treatment option for a patient with end-stage
lung disease. Lung transplant results have improved substantially over time, but ischemia …