[HTML][HTML] Capsaicin: current understanding of its mechanisms and therapy of pain and other pre-clinical and clinical uses
V Fattori, MSN Hohmann, AC Rossaneis… - Molecules, 2016 - mdpi.com
In this review, we discuss the importance of capsaicin to the current understanding of
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …
neuronal modulation of pain and explore the mechanisms of capsaicin-induced pain. We …
Descending control of nociception: specificity, recruitment and plasticity
The dorsal horn of the spinal cord is the location of the first synapse in pain pathways, and
as such, offers a very powerful target for regulation of nociceptive transmission by both local …
as such, offers a very powerful target for regulation of nociceptive transmission by both local …
Unravelling the mystery of capsaicin: a tool to understand and treat pain
A large number of pharmacological studies have used capsaicin as a tool to activate many
physiological systems, with an emphasis on pain research but also including functions such …
physiological systems, with an emphasis on pain research but also including functions such …
[HTML][HTML] Capsaicin, nociception and pain
B Frias, A Merighi - Molecules, 2016 - mdpi.com
Capsaicin, the pungent ingredient of the hot chili pepper, is known to act on the transient
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …
receptor potential cation channel vanilloid subfamily member 1 (TRPV1). TRPV1 is involved …
Cannabinoids and pain: sites and mechanisms of action
K Starowicz, DP Finn - Advances in Pharmacology, 2017 - Elsevier
The endocannabinoid system, consisting of the cannabinoid 1 receptor (CB 1 R) and
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …
cannabinoid 2 receptor (CB 2 R), endogenous cannabinoid ligands (endocannabinoids) …
Immunohistochemical localization of cannabinoid type 1 and vanilloid transient receptor potential vanilloid type 1 receptors in the mouse brain
Cannabinoid type 1 receptors and transient receptor potential vanilloid type 1 channels
have been proposed to act as metabotropic and ionotropic receptors, respectively, for two …
have been proposed to act as metabotropic and ionotropic receptors, respectively, for two …
TRPV1 receptors in the CNS play a key role in broad-spectrum analgesia of TRPV1 antagonists
M Cui, P Honore, C Zhong, D Gauvin… - Journal of …, 2006 - Soc Neuroscience
Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is
considered to be an important integrator of various pain stimuli such as endogenous lipids …
considered to be an important integrator of various pain stimuli such as endogenous lipids …
Elevation of endocannabinoid levels in the ventrolateral periaqueductal grey through inhibition of fatty acid amide hydrolase affects descending nociceptive pathways …
In the ventrolateral periaqueductal gray (PAG), activation of excitatory output neurons
projecting monosynaptically to OFF cells in the rostral ventromedial medulla (RVM) causes …
projecting monosynaptically to OFF cells in the rostral ventromedial medulla (RVM) causes …
Divergent modulation of nociception by glutamatergic and GABAergic neuronal subpopulations in the periaqueductal gray
The ventrolateral periaqueductal gray (vlPAG) constitutes a major descending pain
modulatory system and is a crucial site for opioid-induced analgesia. A number of previous …
modulatory system and is a crucial site for opioid-induced analgesia. A number of previous …
Analgesic actions of N‐arachidonoyl‐serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid TRPV1 receptors
S Maione, L De Petrocellis… - British journal of …, 2007 - Wiley Online Library
Background and purpose: N‐arachidonoyl‐serotonin (AA‐5‐HT) is an inhibitor of fatty acid
amide hydrolase (FAAH)‐catalysed hydrolysis of the endocannabinoid/endovanilloid …
amide hydrolase (FAAH)‐catalysed hydrolysis of the endocannabinoid/endovanilloid …