Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) represents a group
of small vessel vasculitides characterized by granulomatous and neutrophilic tissue …

Psoriasis is a representative inflammatory skin disease occupied by large surface
involvement. As inflammatory cells and cytokines can systemically circulate in various …

Crescentic glomerulonephritis is characterized by vascular necrosis and parietal epithelial
cell hyperplasia in the space surrounding the glomerulus, resulting in the formation of …

Cytokines play an important role in host defense against microorganisms. They orchestrate
innate immunity by inducing protective local inflammation and systemic acute phase …

Chronic kidney disease can progress to end-stage chronic renal disease (ESRD), which
requires the use of replacement therapy (dialysis or kidney transplant) in life-threatening …

Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl
aminopeptidase. The best characterized physiological function of CatC is the activation of …

Systemic lupus erythematosus is a potentially fatal autoimmune disease. Although
interleukin-17 (IL-17) has been linked to human lupus and mouse models of this disease, it …

Systemic lupus erythematosus (SLE) is a very complex disease where multiple
immunological pathways can concur in inducing tissue damage. Cytokines are key …

Th17 cells are a distinct lineage of T-cells. These T-cells express IL-17A and the lineage-
defining transcription factor RORγt. Th17 cells have a pivotal, physiological role in host …

Glomerulonephritis (GN) comprises a group of immune-mediated kidney diseases affecting
glomeruli and the tubulointerstitium. Glomerular crescent formation is a histopathological …