Immune modulation by mesenchymal stem cells

W Jiang, J Xu - Cell proliferation, 2020 - Wiley Online Library
Mesenchymal stem cells (MSCs) can be derived from various adult tissues with multipotent
and self‐renewal abilities. The characteristics of presenting no major ethical concerns …

Mesenchymal stem cells: amazing remedies for bone and cartilage defects

P Kangari, T Talaei-Khozani… - Stem Cell Research & …, 2020 - Springer
Skeletal disorders are among the leading debilitating factors affecting millions of people
worldwide. The use of stem cells for tissue repair has raised many promises in various …

Therapeutic properties of mesenchymal stromal/stem cells: the need of cell priming for cell-free therapies in regenerative medicine

V Miceli, M Bulati, G Iannolo, G Zito, A Gallo… - International Journal of …, 2021 - mdpi.com
Mesenchymal stromal/stem cells (MSCs) are multipotent adult stem cells that support
homeostasis during tissue regeneration. In the last decade, cell therapies based on the use …

Mesenchymal stromal cell secretion of programmed death-1 ligands regulates T cell mediated immunosuppression

LC Davies, N Heldring, N Kadri, K Le Blanc - Stem cells, 2017 - academic.oup.com
Mesenchymal stromal cells (MSCs) exert broad immunosuppressive potential, modulating
the activity of cells of innate and adaptive immune systems. As MSCs become accepted as a …

Mesenchymal stem cell therapy for osteoarthritis: the critical role of the cell secretome

P Mancuso, S Raman, A Glynn, F Barry… - … in bioengineering and …, 2019 - frontiersin.org
Osteoarthritis (OA) is an inflammatory condition still lacking effective treatments.
Mesenchymal stem/stromal cells (MSCs) have been successfully employed in pre-clinical …

TNF-α and IFN-γ participate in improving the immunoregulatory capacity of mesenchymal stem/stromal cells: Importance of cell–cell contact and extracellular vesicles

L López-García, ME Castro-Manrreza - International journal of molecular …, 2021 - mdpi.com
Mesenchymal stem/stromal cells (MSCs) have an immunoregulatory capacity and have
been used in different clinical protocols requiring control of the immune response. However …

The critical role of apoptosis in mesenchymal stromal cell therapeutics and implications in homeostasis and normal tissue repair

C Giacomini, C Granéli, R Hicks, F Dazzi - Cellular & Molecular …, 2023 - nature.com
Mesenchymal stromal cells (MSCs) have been extensively tested for the treatment of
numerous clinical conditions and have demonstrated good safety but mixed efficacy …

Multipotent mesenchymal stromal cells and the innate immune system

K Le Blanc, D Mougiakakos - Nature Reviews Immunology, 2012 - nature.com
Multipotent mesenchymal stromal cells (MSCs) have unique immunoregulatory and
regenerative properties that make them an attractive tool for the cellular treatment of …

Immunoregulation by mesenchymal stem cells: biological aspects and clinical applications

ME Castro-Manrreza… - Journal of immunology …, 2015 - Wiley Online Library
Mesenchymal stem cells (MSCs) are multipotent cells capable of differentiation into
mesenchymal lineages and that can be isolated from various tissues and easily cultivated in …

Immunosuppressive properties of mesenchymal stem cells: advances and applications

MP De Miguel, S Fuentes-Julian… - Current molecular …, 2012 - ingentaconnect.com
Mesenchymal stem cells (MSCs) have been isolated from a variety of tissues, such as bone
marrow, skeletal muscle, dental pulp, bone, umbilical cord and adipose tissue. MSCs are …