Strategies to improve the EPR effect: A mechanistic perspective and clinical translation

M Ikeda-Imafuku, LLW Wang, D Rodrigues… - Journal of Controlled …, 2022 - Elsevier
Many efforts have been made to achieve targeted delivery of anticancer drugs to enhance
their efficacy and to reduce their adverse effects. These efforts include the development of …

Role of interleukin-6 in cancer progression and therapeutic resistance

N Kumari, BS Dwarakanath, A Das, AN Bhatt - Tumor Biology, 2016 - Springer
In the last several decades, the number of people dying from cancer-related deaths has not
reduced significantly despite phenomenal advances in the technologies related to diagnosis …

[HTML][HTML] The fate of chemoresistance in triple negative breast cancer (TNBC)

EA O'Reilly, L Gubbins, S Sharma, R Tully, MHZ Guang… - BBA clinical, 2015 - Elsevier
Background Treatment options for women presenting with triple negative breast cancer
(TNBC) are limited due to the lack of a therapeutic target and as a result, are managed with …

Cell adhesion molecules: role and clinical significance in cancer

N Makrilia, A Kollias, L Manolopoulos… - Cancer …, 2009 - Taylor & Francis
There is a growing body of evidence suggesting that alterations in the adhesion properties
of neoplastic cells endow them with an invasive and migratory phenotype. Indeed, changes …

Current understandings and clinical translation of nanomedicines for breast cancer therapy

Y Jiang, Z Jiang, M Wang, L Ma - Advanced drug delivery reviews, 2022 - Elsevier
Breast cancer is one of the most frequently diagnosed cancers that is threatening women's
life. Current clinical treatment regimens for breast cancer often involve neoadjuvant and …

Role of interleukin-10 in breast cancer

Hamidullah, B Changkija, R Konwar - Breast cancer research and …, 2012 - Springer
Cytokines are low molecular weight regulatory proteins or glycoprotein that modulates the
intensity and duration of immune response by stimulating or inhibiting the activation …

Mechanistic Biomarkers Informative of Both Cancer and Cardiovascular Disease: JACC State-of-the-Art Review

V Narayan, EW Thompson, B Demissei, JE Ho… - Journal of the American …, 2020 - jacc.org
Cardiovascular disease (CVD) and cancer are leading causes of morbidity and mortality
worldwide. Although conventionally managed as separate disease processes, recent …

[HTML][HTML] Predictors of tumor progression during neoadjuvant chemotherapy in breast cancer

AS Caudle, AM Gonzalez-Angulo, KK Hunt… - Journal of clinical …, 2010 - ncbi.nlm.nih.gov
Purpose Although most breast cancer patients who receive neoadjuvant chemotherapy
(NCT) have a tumor response, a small proportion experience progressive disease (PD) …

Optical imaging of breast cancer oxyhemoglobin flare correlates with neoadjuvant chemotherapy response one day after starting treatment

D Roblyer, S Ueda, A Cerussi… - Proceedings of the …, 2011 - National Acad Sciences
Approximately 8–20% of breast cancer patients receiving neoadjuvant chemotherapy fail to
achieve a measurable response and endure toxic side effects without benefit. Most clinical …

Multi-wavelength microflow cytometer using groove-generated sheath flow

JP Golden, JS Kim, JS Erickson, LR Hilliard… - Lab on a Chip, 2009 - pubs.rsc.org
A microflow cytometer was developed that ensheathed the sample (core) fluid on all sides
and interrogated each particle in the sample stream at four different wavelengths. Sheathing …