Molecular pathogenesis of genetic and sporadic aortic aneurysms and dissections

YH Shen, SA LeMaire - Current problems in surgery, 2017 - Elsevier
The aorta is the largest artery and can be divided into several segments (Fig 1). The
diaphragm divides the aorta into the thoracic and abdominal aorta. The thoracic aorta …

[HTML][HTML] Hydrogen gas inhalation attenuates endothelial glycocalyx damage and stabilizes hemodynamics in a rat hemorrhagic shock model

T Tamura, M Sano, T Matsuoka, J Yoshizawa… - Shock, 2020 - journals.lww.com
Background: Hydrogen gas (H 2) inhalation during hemorrhage stabilizes post-resuscitation
hemodynamics, improving short-term survival in a rat hemorrhagic shock and resuscitation …

A transmembrane C-terminal fragment of syndecan-1 is generated by the metalloproteinase ADAM17 and promotes lung epithelial tumor cell migration and lung …

T Pasqualon, J Pruessmeyer, S Weidenfeld… - Cellular and Molecular …, 2015 - Springer
Syndecan-1 is a heparan sulfate proteoglycan expressed by endothelial and epithelial cells
and involved in wound healing and tumor growth. Surface-expressed syndecan-1 …

Enzymatic cleavage of specific dipeptide conjugated with ferrocene as a flexible ultra-sensitive and fast voltammetric assay of matrix metalloproteinase-9 considered a …

MK Nisiewicz, A Kowalczyk, A Gajda… - Biosensors and …, 2022 - Elsevier
Studies over the last decade have shown that matrix metalloproteinases (MMPs) play a key
role in the growth and metastasis of cancer. This zinc-dependent family of endopeptidases is …

Syndecan-4 as a marker of endothelial dysfunction in patients with resistant hypertension

M Lipphardt, H Dihazi, JH Maas, AK Schäfer… - Journal of Clinical …, 2020 - mdpi.com
(1) Background: Arterial hypertension (HTN) is one of the most relevant cardiovascular risk
factors. Nowadays multiple pharmaceutical treatment options exist with novel interventional …

[HTML][HTML] The Potential Involvement of Glycocalyx Disruption in Abdominal Aortic Aneurysm Pathogenesis

B Rabia, S Thanigaimani, J Golledge - Cardiovascular Pathology, 2024 - Elsevier
Background Abdominal aortic aneurysm (AAA) is a weakening and expansion of the
abdominal aorta. Currently, there is no drug treatment to limit AAA growth. The glycocalyx …

Cell surface‐anchored syndecan‐1 ameliorates intestinal inflammation and neutrophil transmigration in ulcerative colitis

Y Zhang, Z Wang, J Liu, S Zhang, J Fei… - Journal of cellular …, 2017 - Wiley Online Library
Abstract Syndecan‐1 (SDC 1), with a variable ectodomain carrying heparan sulphate (HS)
chains between different Syndecans, participates in many steps of inflammatory responses …

[HTML][HTML] Novel electrogravimetric biosensors for the ultrasensitive detection of plasma matrix metalloproteinase-2 considered a potential tumor biomarker

MK Nisiewicz, A Gajda, A Kowalczyk, A Cupriak… - Analytica Chimica …, 2022 - Elsevier
In this study, we developed novel, simple gravimetric and voltammetric sensors for the
ultrasensitive detection of active matrix metalloproteinase (MMP)-2 in plasma. The …

[HTML][HTML] Early diabetic kidney disease: focus on the glycocalyx

H Yu, YY Song, XH Li - World Journal of Diabetes, 2023 - ncbi.nlm.nih.gov
The incidence of diabetic kidney disease (DKD) is sharply increasing worldwide.
Microalbuminuria is the primary clinical marker used to identify DKD, and its initiating step in …

Incipient renal transplant dysfunction associates with tubular syndecan-1 expression and shedding

S Adepu, CWK Rosman, W Dam… - American Journal …, 2015 - journals.physiology.org
Syndecan-1 is a transmembrane heparan sulfate proteoglycan involved in regenerative
growth and cellular adhesion. We hypothesized that the induction of tubular syndecan-1 is a …