Childhood nephrotic syndromes are most commonly caused by one of two idiopathic
diseases: minimal-change nephrotic syndrome (MCNS) and focal segmental …

Mutations in the gene encoding canonical transient receptor potential-6 (TRPC6) channels
result in severe nephrotic syndromes that typically lead to end-stage renal disease. Many …

Based on the literature, recurrent disease is observed in 4–20% of the patients receiving a
kidney transplant and will lead to graft failure in 2–5%[1–6]. In a large study of the University …

Focal segmental glomerulosclerosis (FSGS) is characterized by steroid resistant nephrotic
syndrome and progression to end-stage renal disease. Proteinuria in certain patients with …

Primary forms of focal and segmental glomerulosclerosis (FSGS) are driven by circulating
factors that cause dysfunction or loss podocytes. Rare genetic forms of FSGS can be caused …

For many years, investigators have been searching for an elusive circulating factor that
could cause the common kidney disease focal segmental glomerulosclerosis (FSGS). The …

The redox sensitive glycogen synthase kinase (GSK) 3 has been recently implicated in the
pathogenesis of proteinuric glomerulopathy. However, prior studies are less conclusive …

One of the major challenges modern nephrology should face is the identification of
biomarkers that are associated with histopathological patterns or defined pathogenic …

Uno de los retos a los que debe enfrentarse la nefrología moderna es el de identificar
biomarcadores que se asocien a patrones anatomopatológicos oa mecanismos …

Nephrotic syndrome (NS) is a common chronic glomerular disease in children characterized
by significant proteinuria with resulting hypoalbuminemia, edema, and hyperlipidemia …