The incidence of type 2 diabetes (T2D) has been increasing worldwide, and diabetic kidney
disease (DKD) remains one of the leading long-term complications of T2D. Several lines of …

Organ fibrosis is a process in which cellular homeostasis is disrupted and extracellular
matrix is excessively deposited. Fibrosis can lead to vital organ failure and there are no …

Fibrosis can be defined as a pathological process in which deposition of connective tissue
replaces normal parenchyma. The kidney, like any organ or tissue, can be impacted by this …

Fibrosis is an important and essential reparative response to injury that, if left uncontrolled,
results in the excessive synthesis, deposition, remodeling, and stiffening of the extracellular …

Diabetes is one of the leading causes of chronic kidney disease (CKD), and multiple
underlying mechanisms involved in pathogenesis of diabetic nephropathy (DN) have been …

Renal interstitial fibrosis (RIF) is a common pathological manifestation of chronic kidney
diseases. Epithelial-mesenchymal transition (EMT) of tubular epithelial cells is considered a …

Achieving local therapeutic agent concentration in the kidneys through traditional systemic
administration routes have associated concerns with off-target drug effects and toxicity …

Fibrosis is a physiological process of tissue repair that turns into pathological when
becomes chronic, damaging the functional structure of the tissue. In this review we outline …

Objective. We investigated the effect of roxadustat on factors associated with renal fibrosis
and efficacy. Methods. Sixty patients meeting the inclusion criteria between January 2021 …

Epithelial-mesenchymal transition (EMT) is a complex reversible biological process
characterized by the loss of epithelial features and the acquisition of mesenchymal features …