[HTML][HTML] COVID-19: immunopathogenesis and Immunotherapeutics
L Yang, S Liu, J Liu, Z Zhang, X Wan… - Signal transduction and …, 2020 - nature.com
The recent novel coronavirus disease (COVID-19) outbreak, caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected …
respiratory syndrome coronavirus 2 (SARS-CoV-2), is seeing a rapid increase in infected …
[HTML][HTML] Reprogramming the tumor microenvironment by genome editing for precision cancer therapy
K Liu, JJ Cui, Y Zhan, QY Ouyang, QS Lu, DH Yang… - Molecular Cancer, 2022 - Springer
The tumor microenvironment (TME) is essential for immune escape by tumor cells. It plays
essential roles in tumor development and metastasis. The clinical outcomes of tumors are …
essential roles in tumor development and metastasis. The clinical outcomes of tumors are …
Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients
Y Zhou, B Fu, X Zheng, D Wang, C Zhao… - National Science …, 2020 - academic.oup.com
Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV
(SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity …
(SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity …
Aberrant pathogenic GM-CSF+ T cells and inflammatory CD14+CD16+ monocytes in severe pulmonary syndrome patients of a new coronavirus
Y Zhou, B Fu, X Zheng, D Wang, C Zhao, Y Qi, R Sun… - biorxiv, 2020 - biorxiv.org
Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV
(SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity …
(SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity …
[HTML][HTML] Osteopontin mediates glioblastoma-associated macrophage infiltration and is a potential therapeutic target
J Wei, A Marisetty, B Schrand… - The Journal of …, 2019 - Am Soc Clin Investig
Glioblastoma is highly enriched with macrophages, and osteopontin (OPN) expression
levels correlate with glioma grade and the degree of macrophage infiltration; thus, we …
levels correlate with glioma grade and the degree of macrophage infiltration; thus, we …
The emerging landscape of novel 4-1BB (CD137) agonistic drugs for cancer immunotherapy
C Claus, C Ferrara-Koller, C Klein - MAbs, 2023 - Taylor & Francis
The clinical development of 4–1BB agonists for cancer immunotherapy has raised
substantial interest during the past decade. The first generation of 4–1BB agonistic …
substantial interest during the past decade. The first generation of 4–1BB agonistic …
Lung under attack by COVID-19-induced cytokine storm: pathogenic mechanisms and therapeutic implications
C Pelaia, C Tinello, A Vatrella… - Therapeutic …, 2020 - journals.sagepub.com
The lung is a key target of the cytokine storm that can be triggered by severe acute
respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for the widespread clinical …
respiratory syndrome coronavirus-2 (SARS-CoV-2), responsible for the widespread clinical …
TNF/TNFR family members in costimulation of T cell responses
TH Watts - Annu. Rev. Immunol., 2005 - annualreviews.org
▪ Abstract Several members of the tumor necrosis factor receptor (TNFR) family function after
initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB …
initial T cell activation to sustain T cell responses. This review focuses on CD27, 4-1BB …
Co-stimulatory members of the TNFR family: keys to effective T-cell immunity?
M Croft - Nature Reviews Immunology, 2003 - nature.com
Interactions between co-stimulatory ligands and their receptors are crucial for the activation
of T cells, the prevention of tolerance and the development of T-cell immunity. It is now …
of T cells, the prevention of tolerance and the development of T-cell immunity. It is now …
Timing and tuning of CD27–CD70 interactions: the impact of signal strength in setting the balance between adaptive responses and immunopathology
MA Nolte, RW Van Olffen… - Immunological …, 2009 - Wiley Online Library
After binding its natural ligand cluster of differentiation 70 (CD70), CD27, a tumor necrosis
factor receptor (TNFR)‐associated factor‐binding member of the TNFR family, regulates …
factor receptor (TNFR)‐associated factor‐binding member of the TNFR family, regulates …