The transition metal iron is essential for life, yet potentially toxic iron-catalyzed reactive
oxygen species (ROS) are unavoidable in an oxygen-rich environment. Iron and ROS are …

Yeasts, such as Saccharomyces cerevisiae, have long served as useful models for the study
of oxidative stress, an event associated with cell death and severe human pathologies. This …

Traditionally, researchers have believed that axons are highly dependent on their cell
bodies for long-term survival. However, recent studies point to the existence of axon …

There exists a phenomenon in aging research whereby early life stress can have positive
impacts on longevity. The mechanisms underlying these observations suggest a robust, long …

Apoptosis is associated in many cases with the generation of reactive oxygen species (ROS)
in cells across a wide range of organisms including lower eukaryotes such as the yeast …

Mutant Huntingtin (mtHtt) causes neurodegeneration in Huntington's disease (HD) by
evoking defects in the mitochondria, but the underlying mechanisms remains elusive. Our …

We show that Ydr049 (renamed VCP/Cdc48-associated mitochondrial stress-responsive—
Vms1), a member of an unstudied pan-eukaryotic protein family, translocates from the …

Recent studies have revealed a role for the ubiquitin/proteasome system in the regulation
and turnover of outer mitochondrial membrane (OMM)-associated proteins. Although several …

The hexameric AAA‐ATPase valosin‐containing protein (VCP) is essential for mitochondrial
protein quality control. How VCP is recruited to mammalian mitochondria remains obscure …

Mitochondria are not only important for the energetic status of the cell, but are also the fatal
organelles deciding about cellular life and death. Complex mitochondrial features decisive …