Pyrroloquinoline-quinone is more than an antioxidant: a vitamin-like accessory factor important in health and disease prevention

KR Jonscher, W Chowanadisai, RB Rucker - Biomolecules, 2021 - mdpi.com
Pyrroloquinoline quinone (PQQ) is associated with biological processes such as
mitochondriogenesis, reproduction, growth, and aging. In addition, PQQ attenuates clinically …

Potential Protective Effects of Antioxidants against Cyclophosphamide‐Induced Nephrotoxicity

MA Ayza, KA Zewdie, EF Yigzaw… - International Journal …, 2022 - Wiley Online Library
Cyclophosphamide is an alkylating antineoplastic agent, and it is one of the most successful
drugs with wide arrays of clinical activity. It has been in use for several types of cancer …

Investigation of nephrotoxicity on mice exposed to polystyrene nanoplastics and the potential amelioration effects of DHA-enriched phosphatidylserine

Y Tang, R Zhao, Q Pu, S Jiang, F Yu, Z Yang… - Science of The Total …, 2023 - Elsevier
Nanoplastics (NPs) induce nephrotoxicity in mammals, but an understanding of the potential
mechanism or amelioration strategies is lacking. Herein, we established the polystyrene …

The Effect of Flammulina velutipes Polysaccharide on Immunization Analyzed by Intestinal Flora and Proteomics

Q Liang, Q Zhao, X Hao, J Wang, C Ma, X Xi… - Frontiers in …, 2022 - frontiersin.org
Proteomics and intestinal flora were used to determine the mechanism of immune
modulatory effects of Flammulina velutipes polysaccharide on immunosuppressed mice …

[HTML][HTML] Pyrroloquinoline quinone ameliorates renal fibrosis in diabetic nephropathy by inhibiting the pyroptosis pathway in C57BL/6 mice and human kidney 2 cells

X Qu, B Zhai, Y Liu, Y Chen, Z Xie, Q Wang… - Biomedicine & …, 2022 - Elsevier
Diabetic nephropathy (DN), which is characterized by renal fibrosis, is a major complication
of diabetes, a disease that afflicted more than 460 million people worldwide in 2019 …

The immunoenhancement effects of sea buckthorn pulp oil in cyclophosphamide-induced immunosuppressed mice

J Zhang, HC Zhou, SB He, XF Zhang, YH Ling, XY Li… - Food & Function, 2021 - pubs.rsc.org
In this study, the immunomodulatory effect of sea buckthorn (SBT) pulp oil was elucidated in
immunosuppressed Balb/c mice induced by cyclophosphamide (CTX). The results showed …

Laminaria japonica fucoidan ameliorates cyclophosphamide‐induced liver and kidney injury possibly by regulating Nrf2/HO‐1 and TLR4/NF‐κB signaling pathways

S Tian, X Jiang, Y Tang, T Han - Journal of the Science of Food …, 2022 - Wiley Online Library
BACKGROUND During clinical practice, cyclophosphamide (CTX) can lead to liver and
kidney injury in vivo. In this study, we established a liver and kidney injury model by injecting …

Immunomodulatory activity of a water-soluble polysaccharide extracted from mussel on cyclophosphamide-induced immunosuppressive mice models

X Xiang, R Wang, L Chen, Y Chen, B Zheng… - npj Science of …, 2022 - nature.com
This study aimed to investigate the protective effect of mussel polysaccharide (MP) on
cyclophosphamide (Cy)-induced intestinal mucosal immunosuppression and microbial …

Antidiabetic drug sitagliptin blocks cyclophosphamide cerebral neurotoxicity by activating Nrf2 and suppressing redox cycle imbalance, inflammatory iNOS/NO/NF-κB …

AC Famurewa, NT Asogwa, SC Ezea - International Immunopharmacology, 2023 - Elsevier
Cyclophosphamide (CYP) is a classic DNA-interacting anticancer agent with broad
application in chemotherapy. However, CYP cerebral neurotoxicity is a worrisome side effect …

Oral delivery of nerolidol alleviates cyclophosphamide-induced renal inflammation, apoptosis, and fibrosis via modulation of NF-κB/cleaved caspase-3/TGF-β …

A Iqubal, AK Najmi, S Md, HM Alkreathy, J Ali… - Drug Delivery, 2023 - Taylor & Francis
Cyclophosphamide (CP) is one of the most extensively used antineoplastic drug, but the
nephrotoxicity caused by this drug is a major limiting factor for its use. Nerolidol (NERO) is a …