Adenosine monophosphate-activated protein kinase (AMPK) is a significant energy sensor
in the maintenance of cellular energy homeostasis. Autophagy is a highly conserved …

Each cell is equipped with a conserved housekeeping mechanism, known as autophagy, to
recycle exhausted materials and dispose of injured organelles via lysosomal degradation …

Cell culture‐conditioned medium (CCM) is a valuable source of extracellular vesicles (EVs)
for basic scientific, therapeutic and diagnostic applications. Cell culturing parameters affect …

Macrophage pyroptosis drives the secretion of IL-1β, which has been recently reported to be
a featured salivary biomarker for discriminating periodontitis in the presence of diabetes …

Intervertebral disc degeneration (IVDD) contributes largely to low back pain. Recent studies
have highlighted the exacerbating role of diabetes mellitus (DM) in IVDD, mainly due to the …

Objective Osteoarthritis causes significant pain and disability with no approved disease-
modifying drugs. We systematically reviewed the evidence from both pre-clinical and human …

Quercetin has been preliminarily proven to serve as a potential agent for the treatment of
osteoarthritis (OA). However, its effects and potential mechanisms on the pathological …

Osteoarthritis (OA) is a common disease characterized by cartilage degradation. Growing
evidence showed that glucose metabolism impacts joint homeostasis and an imbalance …

As one of the important means for eukaryotic cells to maintain homeostasis, autophagy
allows for transporting deformed biomacromolecules and damaged organelles to lysosome …

Dysfunction of Schwann cells, including cell apoptosis, autophagy inhibition,
dedifferentiation, and pyroptosis, is a pivotal pathogenic factor in induced diabetic peripheral …