Decades of research have identified genetic factors and biochemical pathways involved in
neurodegenerative diseases (NDDs). We present evidence for the following eight hallmarks …

Executive summary Alzheimer's disease (AD) is the leading cause of dementia, and
because the primary risk factor for AD is old age, the prevalence of the disease is increasing …

Background Traumatic brain injury (TBI) is a leading cause of death and disability
worldwide. Microglial/macrophage activation and neuroinflammation are key cellular events …

The transition between soluble intrinsically disordered tau protein and aggregated tau in
neurofibrillary tangles in Alzheimer's disease is unknown. Here, we propose that soluble tau …

Traumatic brain injuries (TBIs) are clinically grouped by severity: mild, moderate and severe.
Mild TBI (the least severe form) is synonymous with concussion and is typically caused by …

Neuronal inflammation is the characteristic pathologic change of acute neurologic
impairment and chronic traumatic encephalopathy after traumatic brain injury (TBI) …

Traumatic brain injury (TBI) and Alzheimer's disease (AD) are devastating neurological
disorders, whose complex relationship is not completely understood. Cerebrovascular …

Traumatic brain injury, a leading cause of mortality and morbidity, is divided into three
grades of severity: mild, moderate, and severe, based on the Glasgow Coma Scale, the loss …

Importance Traumatic brain injury (TBI) is a significant public health concern that affects
individuals in all demographics. With increasing interest in the medical and public …

Axonal white matter injury is believed to be a major determinant of adverse outcomes
following traumatic brain injury (TBI). We hypothesized that measurement of neurofilament …