Rationale: Accurate, early identification of patients at risk for developing acute lung injury
(ALI) provides the opportunity to test and implement secondary prevention strategies …

Background: Red blood cell (RBC) transfusions are common in intensive care unit, trauma,
and surgical patients. However, the hematocrit that should be maintained in any particular …

Acute respiratory distress syndrome and acute lung injury are well defined and readily
recognised clinical disorders caused by many clinical insults to the lung or because of …

Introduction Recent cohort studies have identified the use of large tidal volumes as a major
risk factor for development of lung injury in mechanically ventilated patients without acute …

Rationale: Reducing tidal volume decreases mortality in acute respiratory distress syndrome
(ARDS). However, the effect of the timing of low tidal volume ventilation is not well …

Objective: Protective mechanical ventilation with low tidal volumes is standard of care for
patients with acute respiratory distress syndrome. The aim of this individual patient data …

Background: Transfusion-related acute lung injury (TRALI) is now the leading cause of
transfusion-associated mortality, even though it is probably still underdiagnosed and …

Objective: To describe mechanical ventilation settings in adult patients treated for an acute
respiratory distress syndrome with extracorporeal membrane oxygenation and assess the …

Background: The relationship between body mass index (BMI) and development of acute
respiratory distress syndrome (ARDS) is unknown. Methods: A cohort study of critically ill …

Despite significant advances in our understanding and management of patients with acute
respiratory distress syndrome (ARDS), the morbidity and mortality from ARDS remains high …