Leigh syndrome is a rare, complex, and incurable early onset (typically infant or early
childhood) mitochondrial disorder with both phenotypic and genetic heterogeneity. The …

Abstract Transfer (t) RNAs are 70–90 nucleotide small RNAs highly regulated by 43 different
types of epitranscriptomic modifications and requiring aminoacylation ('charging') for mRNA …

In the present study, we assembled and analyzed the mitogenomes of two Ramaria species.
The assembled mitogenomes of Ramaria cfr. rubripermanens and R. rubella were …

The MELAS syndrome primarily affecting the CNS is mainly caused by the m. A3243G
mutation. The heteroplasmy in different tissues affects the phenotypic spectrum, yet the …

Background Mitochondrial dysfunctions caused by mitochondrial DNA (mtDNA) pathogenic
mutations play putative roles in type 2 diabetes mellitus (T2DM) progression. But the …

Mitochondrial diseases are a heterogeneous group of rare genetic disorders caused by
mutations in nuclear or mitochondrial DNA (mtDNA). These diseases are frequently …

Mitochondria play a crucial role in maintaining the energy status and redox homeostasis of
eukaryotic cells. They are responsible for the metabolic efficiency of cells, providing both …

As one of the most vital organelles within biological cells, mitochondria hold an
irreplaceable status and play crucial roles in various diseases. Research and therapies …

Mitochondrial homeostasis-including function, morphology, and inter-organelle
communication-provides guidance to the intrinsic developmental programs of …

Introduction: Impairment of mitochondrial function caused by pathogenic mitochondrial DNA
(mtDNA) mutations has been found to be associated with pre-eclampsia (PE). However, the …