Abstract PROteolysis TArgeting Chimeras (PROTACs) technology is a new protein-
degradation strategy that has emerged in recent years. It uses bifunctional small molecules …

Cancer cell possesses numerous adaptations to resist the immune system response and
chemotherapy. One of the most significant properties of the neoplastic cells is the altered …

Reprogramming of lipid metabolism is a newly recognized hallmark of malignancy.
Increased lipid uptake, storage and lipogenesis occur in a variety of cancers and contribute …

Less than a century ago, gastric cancer was the most common cancer in the United States
and perhaps throughout the world. Despite its worldwide decline in incidence over the past …

Numerous and different types of cancers possess the dysregulation of the mevalonate
pathway as a common feature. Statins, traditionally applied in cardiovascular diseases to …

Drug-induced gingival overgrowth is a tissue-specific condition and is estimated to affect
approximately one million North Americans. Lesions occur principally as side-effects from …

Evidence from preclinical studies suggests that the competitive HMG-CoA reductase
(HMGCR) inhibitors universally known as' statins,'in addition to being powerful drugs that …

Cholesterol is an amphipathic sterol molecule that is vital for maintaining normal
physiological homeostasis. It is a relatively complicated molecule with 27 carbons whose …

Purpose Breast cancer is the most common cancer in females and the leading cause of
death worldwide. The effects of statins on breast cancer prognosis have long been …

Lipid metabolism disorder is related to an increased risk of tumorigenesis and is involved in
the rapid growth of cancer cells as well as the formation of metastatic lesions …