[HTML][HTML] IKZF1 Alterations and Therapeutic Targeting in B-Cell Acute Lymphoblastic Leukemia
IKZF1 encodes the transcription factor IKAROS, a zinc finger DNA-binding protein with a key
role in lymphoid lineage development. IKAROS plays a critical role in the development of …
role in lymphoid lineage development. IKAROS plays a critical role in the development of …
Conserved helical motifs in the Ikaros IDR mediate NuRD interaction and transcriptional repression
T Zhang, YF Wang, A Montoya, N Nebioglu… - bioRxiv, 2024 - biorxiv.org
The transcription factor IKZF1/Ikaros is essential for B cell development, and recurrently
mutated in human B-ALL. Ikaros has been ascribed both activating and repressive functions …
mutated in human B-ALL. Ikaros has been ascribed both activating and repressive functions …