The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

The characteristic features of Alzheimer's disease (AD) are the appearance of extracellular
amyloid-beta (Aβ) plaques and neurofibrillary tangles in the intracellular environment …

Alzheimer's disease (AD) is characterized by extracellular amyloid-β (Aβ) plaques and
intracellular tau inclusions. However, the exact mechanistic link between these two AD …

Parkinson's disease is characterized by abundant α-synuclein (α-Syn) neuronal inclusions,
known as Lewy bodies and Lewy neurites, and the massive loss of midbrain dopamine …

Transgenic Tg2576 mice overexpressing human amyloid precursor protein (hAPP) are a
widely used Alzheimer's disease (AD) mouse model to evaluate treatment effects on amyloid …

Here we describe a staged, behavioral testing approach that can be used to screen for
compounds that exhibit in vivo efficacy on cognitive and functional motor behaviors in …

Neurodegenerative tauopathies, such as Alzheimer's disease (AD), are characterized by
insoluble deposits of hyperphosphorylated tau protein within brain neurons. Increased …

Both insulin resistance (type II diabetes) and β-amyloid (Aβ) oligomers are implicated in
Alzheimer's disease (AD). Here, we investigate the role of Aβ oligomer-induced c-Jun N …

A growing body of evidence supports a role for glial-produced neuroimmune factors,
including the cytokine IL-6, in CNS physiology and pathology. CNS expression of IL-6 has …

Aged garlic extract (AGE) is an odorless garlic preparation containing S‐allylcysteine (SAC)
as its most abundant compound. A large number of studies have demonstrated the …