Advances in biomaterial‐based spinal cord injury repair

H Shen, C Fan, Z You, Z Xiao… - Advanced Functional …, 2022 - Wiley Online Library
Spinal cord injury (SCI) often leads to the loss of motor and sensory functions and is a major
challenge in neurological clinical practice. Understanding the pathophysiological changes …

[HTML][HTML] Stem cell-derived neuronal relay strategies and functional electrical stimulation for treatment of spinal cord injury

BQ Lai, X Zeng, WT Han, MT Che, Y Ding, G Li… - Biomaterials, 2021 - Elsevier
The inability of adult mammals to recover function lost after severe spinal cord injury (SCI)
has been known for millennia and is mainly attributed to a failure of brain-derived nerve fiber …

Developing a mechanically matched decellularized spinal cord scaffold for the in situ matrix-based neural repair of spinal cord injury

Y Ma, H Shi, Q Wei, Q Deng, J Sun, Z Liu, B Lai, G Li… - Biomaterials, 2021 - Elsevier
Tissue engineering is a promising strategy to repair spinal cord injury (SCI). However, a
bioscaffold with mechanical properties that match those of the pathological spinal cord …

Polycaprolactone electrospun fiber scaffold loaded with iPSCs-NSCs and ASCs as a novel tissue engineering scaffold for the treatment of spinal cord injury

XH Zhou, GD Shi, BY Fan, X Cheng… - International journal …, 2018 - Taylor & Francis
Background Spinal cord injury (SCI) is a traumatic disease of the central nervous system,
accompanied with high incidence and high disability rate. Tissue engineering scaffold can …

Advances in 3D bioprinting for neural tissue engineering

SJ Lee, T Esworthy, S Stake, S Miao… - Advanced …, 2018 - Wiley Online Library
Current therapies for nerve regeneration within injured tissues have had limited success due
to complicated neural anatomy and inhibitory barriers in situ. Recent advancements in 3D …

[HTML][HTML] Tissue-engineered regeneration of completely transected spinal cord using induced neural stem cells and gelatin-electrospun poly (lactide-co-glycolide) …

C Liu, Y Huang, M Pang, Y Yang, S Li, L Liu, T Shu… - PloS one, 2015 - journals.plos.org
Tissue engineering has brought new possibilities for the treatment of spinal cord injury. Two
important components for tissue engineering of the spinal cord include a suitable cell source …

Spinal cord injury repair by implantation of structured hyaluronic acid scaffold with PLGA microspheres in the rat

Y Wen, S Yu, Y Wu, R Ju, H Wang, Y Liu… - Cell and Tissue …, 2016 - Springer
In order to create an optimal microenvironment for neural regeneration in the lesion area
after spinal cord injury (SCI), we fabricated a novel scaffold composed of a hyaluronic acid …

Transplantation of tissue engineering neural network and formation of neuronal relay into the transected rat spinal cord

BQ Lai, MT Che, BL Du, X Zeng, YH Ma, B Feng… - Biomaterials, 2016 - Elsevier
Severe spinal cord injury (SCI) causes loss of neural connectivity and permanent functional
deficits. Re-establishment of new neuronal relay circuits after SCI is therefore of paramount …

[HTML][HTML] Complete rat spinal cord transection as a faithful model of spinal cord injury for translational cell transplantation

D Lukovic, V Moreno-Manzano, E Lopez-Mocholi… - Scientific reports, 2015 - nature.com
Spinal cord injury (SCI) results in neural loss and consequently motor and sensory
impairment below the injury. There are currently no effective therapies for the treatment of …

A modular assembly of spinal cord–like tissue allows targeted tissue repair in the transected spinal cord

BQ Lai, B Feng, MT Che, LJ Wang, S Cai… - Advanced …, 2018 - Wiley Online Library
Tissue engineering–based neural construction holds promise in providing organoids with
defined differentiation and therapeutic potentials. Here, a bioengineered transplantable …