A growing number of epidemiological and experimental studies has established that
circadian disruption is strongly associated with psychiatric disorders, including major …

Mood disorders are often characterised by alterations in circadian rhythms, sleep
disturbances and seasonal exacerbation. Conversely, chronobiological treatments utilise …

Several studies have demonstrated the effectiveness of ketamine in rapidly alleviating
depression and suicidal ideation. Intense research efforts have been undertaken to expose …

Disruption of circadian clocks is strongly associated with mood disorders. Chronotherapies
targeting circadian rhythms have been shown to be very effective treatments of mood …

Therapeutic sleep deprivation (SD) rapidly induces robust, transient antidepressant effects
in a large proportion of major mood disorder patients suffering from a depressive episode …

Sleep disorders may induce anxiety-and depressive-like behaviors. Furthermore, sleep
disorders can alter the function of α-KGDH (α-ketoglutarate dehydrogenase), which is …

Bright light therapy (BLT) and pharmacological therapies currently represent the first line
treatments for patients with seasonal affective disorder (SAD). Lifestyle modifications offer a …

Background: Total sleep deprivation (TSD) combined with bright light therapy (BLT) has
been suggested as a valuable add-on to standard treatment for rapid relief of depression …

Major depressive disorder (MDD) is a complex mood disorder. While much progress has
been made in understanding the pathophysiology of MDD, no single mechanism can …

В настоящее время накоплено достаточно данных, позволяющих предположить, что
нарушение механизмов, участвующих в регуляции цикла сон-бодрствование совпадает …