[HTML][HTML] Aerosol pulmonary immune engineering
ER Sudduth, M Trautmann-Rodriguez, N Gill… - Advanced Drug Delivery …, 2023 - Elsevier
Aerosolization of immunotherapies poses incredible potential for manipulating the local
mucosal-specific microenvironment, engaging specialized pulmonary cellular defenders …
mucosal-specific microenvironment, engaging specialized pulmonary cellular defenders …
Recent advances in respiratory immunization: A focus on COVID-19 vaccines
X He, X Chen, H Wang, G Du, X Sun - Journal of Controlled Release, 2023 - Elsevier
The development of vaccines has always been an essential task worldwide since vaccines
are regarded as powerful weapons in protecting the global population. Although the vast …
are regarded as powerful weapons in protecting the global population. Although the vast …
[HTML][HTML] Nanobodies to multiple spike variants and inhalation of nanobody-containing aerosols neutralize SARS-CoV-2 in cell culture and hamsters
The ongoing threat of COVID-19 has highlighted the need for effective prophylaxis and
convenient therapies, especially for outpatient settings. We have previously developed …
convenient therapies, especially for outpatient settings. We have previously developed …
[HTML][HTML] Recombinant neutralizing secretory IgA antibodies for preventing mucosal acquisition and transmission of SARS-CoV-2
K Göritzer, E Groppelli, C Grünwald-Gruber, R Figl… - Molecular Therapy, 2024 - cell.com
Passive delivery of antibodies to mucosal sites may be a valuable adjunct to COVID-19
vaccination to prevent infection, treat viral carriage, or block transmission. Neutralizing …
vaccination to prevent infection, treat viral carriage, or block transmission. Neutralizing …
[HTML][HTML] Broadly neutralizing humanized SARS-CoV-2 antibody binds to a conserved epitope on spike and provides antiviral protection through inhalation-based …
P Hermet, B Delache, C Herate, E Wolf, G Kivi… - PLoS …, 2023 - journals.plos.org
The COVID-19 pandemic represents a global challenge that has impacted and is expected
to continue to impact the lives and health of people across the world for the foreseeable …
to continue to impact the lives and health of people across the world for the foreseeable …
[HTML][HTML] Long-acting inhaled medicines: present and future
C Zhang, D D'Angelo, F Buttini, M Yang - Advanced Drug Delivery Reviews, 2023 - Elsevier
Inhaled medicines continue to be an essential part of treatment for respiratory diseases such
as asthma, chronic obstructive pulmonary disease, and cystic fibrosis. In addition, inhalation …
as asthma, chronic obstructive pulmonary disease, and cystic fibrosis. In addition, inhalation …
Barriers for orally inhaled therapeutic antibodies
T Sécher, N Heuzé-Vourc'h - Expert Opinion on Drug Delivery, 2023 - Taylor & Francis
Introduction Respiratory diseases represent a worldwide health issue. The recent Sars-CoV-
2 pandemic, the burden of lung cancer, and inflammatory respiratory diseases urged the …
2 pandemic, the burden of lung cancer, and inflammatory respiratory diseases urged the …
[HTML][HTML] Recent progress in drying technologies for improving the stability and delivery efficiency of biopharmaceuticals
F Emami, M Keihan Shokooh… - Journal of Pharmaceutical …, 2023 - Springer
Background Most biopharmaceuticals are developed in liquid dosage forms that are less
stable than solid forms. To ensure the stability of biopharmaceuticals, it is critical to use an …
stable than solid forms. To ensure the stability of biopharmaceuticals, it is critical to use an …
Strategies for overcoming the biological barriers associated with the administration of inhaled monoclonal antibodies for lung diseases
MG Matera, L Calzetta, B Rinaldi… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction Monoclonal antibodies (mAbs) should be administered by inhalation rather than
parenterally to improve their efficiency in lung diseases. However, the pulmonary …
parenterally to improve their efficiency in lung diseases. However, the pulmonary …