Increased cytokine production possibly due to oxidative stress has repeatedly been shown
to play a pivotal role in the pathophysiology of epilepsy and bipolar disorder. Recent in vitro …

Depressive mothers often find mother-child interaction to be challenging. Maternal stress
may further impair mother-child attachment, which may increase the risk of negative …

Crohn's disease (CD) is associated with increased psychiatric co-morbidities. Nitric oxide
(NO) is implicated in inflammation and tissue injury in CD, and it may also play a central role …

Biologic tumor necrosis factor (TNF)-α inhibitors do not cross the blood-brain barrier (BBB).
A BBB-penetrating TNF-α inhibitor was engineered by fusion of the extracellular domain of …

In various toxicological studies, single housing of rodents is preferred to standardize for
regulatory purposes. However, housing conditions can have severe, often underestimated …

Tumor necrosis factor-α (TNF-α) is a glycoprotein hormone with important functions in
inflammation and apoptosis. It plays a significant role as a pro-inflammatory cytokine in the …

BACKGROUND: Selective serotonin reuptake inhibitors (SSRIs) exert cardioprotective
effects. We examined whether SSRIs a) modulate endothelial cell expression of vascular …

This article presents a summary of the evidence that can be used to establish a link between
the recently introduced autoinflammatory diseases (AIDs) and psoriasis, a member of the …

OBJECTIVE: To determine the serum levels of Th1 (IL-12, IFN-γ, TNF-α) and Th2 (IL-5, IL-6
and IL-10) cytokines in childhood-onset SLE, first-degree relatives and healthy controls. To …

There is some evidence that an immune response with an increased production of
proinflammatory cytokines frequently accompanies major depression. The aim of this study …