Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca,
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …

Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …

Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …

Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

This report provides a historical overview of research concerning the endogenous
hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis …

Abstract N, N-dimethyltryptamine (DMT) is an indole alkaloid widely found in plants and
animals. It is best known for producing brief and intense psychedelic effects when ingested …

Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

The sigma-1 receptor, an endoplasmic reticulum-associated molecular chaperone, is
attracting great interest as a potential target for neuroprotective treatments. We provide the …

This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …

The σ1 receptor is a poorly understood membrane protein expressed throughout the human
body. Ligands targeting the σ1 receptor are in clinical trials for treatment of Alzheimer's …