[HTML][HTML] Psychedelics and neuroplasticity: a systematic review unraveling the biological underpinnings of psychedelics
Clinical studies suggest the therapeutic potential of psychedelics, including ayahuasca,
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …
DMT, psilocybin, and LSD, in stress-related disorders. These substances induce cognitive …
Psychedelics in psychiatry: neuroplastic, immunomodulatory, and neurotransmitter mechanisms
Mounting evidence suggests safety and efficacy of psychedelic compounds as potential
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
novel therapeutics in psychiatry. Ketamine has been approved by the Food and Drug …
[HTML][HTML] Neuronal sigma-1 receptors: signaling functions and protective roles in neurodegenerative diseases
DA Ryskamp, S Korban, V Zhemkov… - Frontiers in …, 2019 - frontiersin.org
Sigma-1 receptor (S1R) is a multi-functional, ligand-operated protein situated in
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
endoplasmic reticulum (ER) membranes and changes in its function and/or expression have …
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
N, N-dimethyltryptamine (DMT), an endogenous hallucinogen: past, present, and future research to determine its role and function
SA Barker - Frontiers in neuroscience, 2018 - frontiersin.org
This report provides a historical overview of research concerning the endogenous
hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis …
hallucinogen N, N-dimethyltryptamine (DMT), focusing on data regarding its biosynthesis …
Neuropharmacology of N, N-dimethyltryptamine
TM Carbonaro, MB Gatch - Brain research bulletin, 2016 - Elsevier
Abstract N, N-dimethyltryptamine (DMT) is an indole alkaloid widely found in plants and
animals. It is best known for producing brief and intense psychedelic effects when ingested …
animals. It is best known for producing brief and intense psychedelic effects when ingested …
Perturbations of native membrane protein structure in alkyl phosphocholine detergents: a critical assessment of NMR and biophysical studies
Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …
Pharmacological stimulation of sigma-1 receptors has neurorestorative effects in experimental parkinsonism
V Francardo, F Bez, T Wieloch, H Nissbrandt… - Brain, 2014 - academic.oup.com
The sigma-1 receptor, an endoplasmic reticulum-associated molecular chaperone, is
attracting great interest as a potential target for neuroprotective treatments. We provide the …
attracting great interest as a potential target for neuroprotective treatments. We provide the …
Sigma receptors [σ Rs]: biology in normal and diseased states
CG Rousseaux, SF Greene - Journal of Receptors and Signal …, 2016 - Taylor & Francis
This review compares the biological and physiological function of Sigma receptors [σRs] and
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …
their potential therapeutic roles. Sigma receptors are widespread in the central nervous …
Structural basis for σ1 receptor ligand recognition
The σ1 receptor is a poorly understood membrane protein expressed throughout the human
body. Ligands targeting the σ1 receptor are in clinical trials for treatment of Alzheimer's …
body. Ligands targeting the σ1 receptor are in clinical trials for treatment of Alzheimer's …