Pancreatic ductal adenocarcinoma (PDAC) has an extraordinarily dense fibrotic stroma that
impedes tumor perfusion and delivery of anticancer drugs. Since the extracellular matrix …

Simple Summary Stroma modifications observed in solid cancer are now recognized as
critical events for cancer progression and as potential therapeutic or diagnostic targets. The …

Pancreatic ductal adenocarcinoma (PDAC) is notorious for a dense fibrotic stroma that is
interlaced with a collagen-based extracellular matrix (ECM) that plays an important role in …

Pancreatic ductal adenocarcinoma is a devastating disease, and patient outcomes have not
improved in decades. Treatments that target tumor cells have largely failed. This could be …

Galectins are a family of proteins that bind to specific glycans thereby deciphering the
information captured within the glycome. In the last two decades, several galectin family …

Pancreatic adenocarcinoma is a lethal disease with a 5‑year survival rate of< 5%, the lowest
of all types of cancer. The diagnosis of pancreatic cancer relies on imaging and tissue …

Traditional chemotherapeutics have largely failed to date to produce significant
improvements in pancreatic cancer survival. One of the reasons for the resilience of …

Pancreatic cancer is characterised by a prominent desmoplastic/stromal reaction that has
received little attention until recent times. Given that treatments focusing on pancreatic …

The incidence and mortality of cancer have increased over the past decades. Significant
progress has been made in understanding the underpinnings of this disease and …

The incidence of pancreatic cancer has been increasing while its 5-year survival rate has
not changed in decades. In the era of personalized medicine, immunotherapy has emerged …