Abstract Vitamin B12 (cobalamin, Cbl) is a nutrient essential to human health. Due to its
complex structure and dual cofactor forms, Cbl undergoes a complicated series of …

Abstract NAD (P) H-dependent oxidoreductases catalyze the reduction or oxidation of a
substrate coupled to the oxidation or reduction, respectively, of a nicotinamide adenine …

Background Remethylation defects are rare inherited disorders in which impaired
remethylation of homocysteine to methionine leads to accumulation of homocysteine and …

Conceptually, the simplest way to synthesize an organic molecule is to construct it one
carbon at a time. The Wood–Ljungdahl pathway of CO2 fixation involves this type of …

▪ Abstract Vitamin B12 is a complex organometallic cofactor associated with three
subfamilies of enzymes: the adenosylcobalamin-dependent isomerases, the …

Biochemistry: The Chemical Reactions of Living Cells is a well-integrated, up-to-date
reference for basic biochemistry, associated chemistry, and underlying biological …

Vitamin B12, or cobalamin, is one of the most structurally complex small molecules made in
Nature. Major progress has been made over the past decade in understanding how this …

Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

Vitamin B2 (riboflavin) is an essential dietary compound used for the enzymatic biosynthesis
of FMN and FAD. The human genome contains 90 genes encoding for flavin-dependent …

In the early 1930s, Banting and Best, the discoverers of insulin, found that choline could
prevent the development of fatty liver disease (steatosis) in pancreatectomized dogs treated …