The medicinal use of Cannabis sativa L. can be traced back thousands of years to ancient
China and Egypt. While marijuana has recently shown promise in managing chronic pain …

There are at least two types of cannabinoid receptors (CB1 and CB2). Ligands activating
these G protein-coupled receptors (GPCRs) include the phytocannabinoid Δ9 …

It is widely accepted that non-endogenous compounds that target CB1 and/or CB2 receptors
possess therapeutic potential for the clinical management of an ever growing number of …

ABSTRACT Cannabidiol (CBD), the non-psychoactive component of Cannabis sativa, acts
on a diverse selection of membrane proteins with promising therapeutic potential in epilepsy …

Cannabinoids are a structurally diverse group of mostly lipophilic molecules that bind to
cannabinoid receptors. In fact, endogenous cannabinoids (endocannabinoids) are a class of …

The patch-clamp technique represents an electrophysiology type of method. This is one of
several insightful approaches with five major configurations, namely a loose patch, cell …

Background Purified cannabidiol (CBD), a non-psychoactive phytocannabinoid, has gained
regulatory approval to treat intractable childhood epilepsies. Despite this, artisanal and …

Introduction: Cannabis contains cannabidiol (CBD), the main non-psychoactive
phytocannabinoid, but also many other phytocannabinoids that have therapeutic potential in …

The energy required for active Na chloride reabsorption in the thick ascending limb (TAL)
depends on oxygen consumption and oxidative phosphorylation (OXP). In other cells, Na …

Migraine is a disabling neurovascular disorder characterized by severe pain with still limited
efficient treatments. Endocannabinoids, the endogenous painkillers, emerged, alternative to …