Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression
Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …
New antiarrhythmic drugs for treatment of atrial fibrillation
Inadequacies in current therapies for atrial fibrillation have made new drug development
crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia. In …
crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia. In …
Cellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation
Background—Electrical, structural, and Ca2+-handling remodeling contribute to the
perpetuation/progression of atrial fibrillation (AF). Recent evidence has suggested a role for …
perpetuation/progression of atrial fibrillation (AF). Recent evidence has suggested a role for …
CaMKII-Dependent Diastolic SR Ca2+ Leak and Elevated Diastolic Ca2+ Levels in Right Atrial Myocardium of Patients With Atrial Fibrillation
S Neef, N Dybkova, S Sossalla, KR Ort… - Circulation …, 2010 - Am Heart Assoc
Rationale: Although research suggests that diastolic Ca2+ levels might be increased in atrial
fibrillation (AF), this hypothesis has never been tested. Diastolic Ca2+ leak from the …
fibrillation (AF), this hypothesis has never been tested. Diastolic Ca2+ leak from the …
Calmodulin kinase II–mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice
Atrial fibrillation (AF), the most common human cardiac arrhythmia, is associated with
abnormal intracellular Ca2+ handling. Diastolic Ca2+ release from the sarcoplasmic …
abnormal intracellular Ca2+ handling. Diastolic Ca2+ release from the sarcoplasmic …
Novel molecular targets for atrial fibrillation therapy
Atrial fibrillation is the most common type of cardiac arrhythmia, and is responsible for
substantial morbidity and mortality in the general population. Current treatments have …
substantial morbidity and mortality in the general population. Current treatments have …
The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with
substantial morbidity and mortality. It causes profound changes in sarcoplasmic reticulum …
substantial morbidity and mortality. It causes profound changes in sarcoplasmic reticulum …
Function and regulation of serine/threonine phosphatases in the healthy and diseased heart
J Heijman, M Dewenter, A El-Armouche… - Journal of molecular and …, 2013 - Elsevier
Protein phosphorylation is a major control mechanism of a wide range of physiological
processes and plays an important role in cardiac pathophysiology. Serine/threonine protein …
processes and plays an important role in cardiac pathophysiology. Serine/threonine protein …
Intracellular calcium leak due to FKBP12. 6 deficiency in mice facilitates the inducibility of atrial fibrillation
S Sood, MG Chelu, RJ van Oort, D Skapura… - Heart rhythm, 2008 - Elsevier
BACKGROUND: Although defective Ca2+ homeostasis may contribute to arrhythmogenesis
in atrial fibrillation (AF), the underlying molecular mechanisms remain poorly understood …
in atrial fibrillation (AF), the underlying molecular mechanisms remain poorly understood …
Mechanisms and treatments of oxidative stress in atrial fibrillation
X Ren, X Wang, M Yuan, C Tian, H Li… - Current …, 2018 - ingentaconnect.com
Atrial fibrillation (AF) is a frequent cardiac arrhythmia. It is a common major cause of serious
diseases and is an increasing health-care burden. AF is associated with an excess amount …
diseases and is an increasing health-care burden. AF is associated with an excess amount …