Atrial fibrillation (AF) is the most common clinically relevant arrhythmia and is associated
with increased morbidity and mortality. The incidence of AF is expected to continue to rise …

Inadequacies in current therapies for atrial fibrillation have made new drug development
crucial. Conventional antiarrhythmic drugs increase the risk of ventricular proarrhythmia. In …

Background—Electrical, structural, and Ca2+-handling remodeling contribute to the
perpetuation/progression of atrial fibrillation (AF). Recent evidence has suggested a role for …

Rationale: Although research suggests that diastolic Ca2+ levels might be increased in atrial
fibrillation (AF), this hypothesis has never been tested. Diastolic Ca2+ leak from the …

Atrial fibrillation (AF), the most common human cardiac arrhythmia, is associated with
abnormal intracellular Ca2+ handling. Diastolic Ca2+ release from the sarcoplasmic …

Atrial fibrillation is the most common type of cardiac arrhythmia, and is responsible for
substantial morbidity and mortality in the general population. Current treatments have …

Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with
substantial morbidity and mortality. It causes profound changes in sarcoplasmic reticulum …

Protein phosphorylation is a major control mechanism of a wide range of physiological
processes and plays an important role in cardiac pathophysiology. Serine/threonine protein …

BACKGROUND: Although defective Ca2+ homeostasis may contribute to arrhythmogenesis
in atrial fibrillation (AF), the underlying molecular mechanisms remain poorly understood …

Atrial fibrillation (AF) is a frequent cardiac arrhythmia. It is a common major cause of serious
diseases and is an increasing health-care burden. AF is associated with an excess amount …