Lipid droplets (LDs) and peroxisomes are central players in cellular lipid homeostasis: some
of their main functions are to control the metabolic flux and availability of fatty acids (LDs and …

Peroxisomes are remarkably dynamic, multifunctional organelles, which react to
physiological changes in their cellular environment and adopt their morphology, number …

Pex11 is a peroxin that regulates the number of peroxisomes in eukaryotic cells. Recently, it
was found that a mutation in one of the three mammalian paralogs, PEX11β, results in a …

The central role of peroxisomes in the generation and scavenging of hydrogen peroxide has
been well known ever since their discovery almost four decades ago. Recent studies have …

PEX genes encode proteins, termed peroxins, that are required for the biogenesis and
proliferation of microbodies (peroxisomes). We have screened the available protein and …

Peroxisomes perform a large variety of metabolic functions that require a constant flow of
metabolites across the membranes of these organelles. Over the last few years it has …

Dynamic changes of membrane structure are intrinsic to organelle morphogenesis and
homeostasis. Ectopic expression of proteins of the PEX11 family from yeast, plant or human …

Crucial metabolic functions of peroxisomes rely on a variety of peroxisomal membrane
proteins (PMPs). While mRNA transcripts of PMPs were shown to be colocalized with …

The peroxisomal disorders represent a group of genetic diseases in humans in which there
is an impairment in one or more peroxisomal functions. The peroxisomal disorders are …

Targeting of peroxisomal membrane proteins (PMPs) is a multistep process that requires not
only recognition of PMPs in the cytosol but also their insertion into the peroxisomal …