Simple Summary Therapeutic targeting of Wnt has long been suggested for gastrointestinal
(GI) cancer treatment because deregulation of Wnt signaling is associated with GI cancers …

Dickkopf-1 (DKK1), an inhibitor of the most frequently impaired signaling pathway in
hepatocellular carcinoma (HCC), the Wnt/beta-catenin pathway, seems to fulfill contradictory …

Liver cancer is the fifth most widespread in the world, with a high fatality rate and poor
prognosis. However, surgicalresction, thermal/radiofrequencyablation, chemo …

Nonalcoholic fatty liver disease (NAFLD) is one of the etiologies that contribute to
hepatocellular carcinoma (HCC), and chronic inflammation is one of the proposed mediators …

Activation of Wnt signaling triggers macropinocytosis and drives many tumors. We now
report that the exogenous addition of the second messenger lipid sn-1, 2 DAG to the culture …

Hepatocellular carcinoma (HCC) belongs to the most frequent cancer with a high death rate
worldwide. Thousands of long non-coding RNAs (lncRNAs) have been confirmed to …

Background Kinesins play important roles in the development and progression of many
human cancers. The functions and underlying mechanisms of kinesin family member C1 …

The trans-activation response DNA-binding protein of 43 kDa (TDP-43) is a nuclear protein
that has been shown to be involved in the growth and metastasis of breast cancer …

Highlights: Multi tyrosine kinase inhibitors licensed for HCC treatment. Multi kinase inhibitors
not licensed for HCC treatment. Inhibitors of Growth Factor Receptors. Small molecules …

Rationale: Protein kinases are critical therapeutic targets for curing hepatocellular
carcinoma (HCC). As a serine/threonine kinase, the potential roles of serine/threonine …