[Frontiers in Bioscience 11, 1388-1413, May 1, 2006] 1388 Prostate cancer epidemiology Ann
W. Hsing 1 and Anand P. Chokkalingam Page 1 [Frontiers in Bioscience 11, 1388-1413, May 1 …

The purpose of this review is to discuss the epidemiologic literature on the association of sex
steroid hormones and components of their signaling and metabolic pathways with prostate …

Background: Height, a marker of childhood environmental exposures, is positively
associated with prostate cancer risk, perhaps through the insulin-like growth factor system …

Methods A review of the literature was undertaken to evaluate the role that genetic
susceptibility may play in prostate cancer etiology and outcomes, with a particular emphasis …

The prostate gland is an androgen-dependent, and polymorphisms in androgen synthesis
gene steroid 5-α reductase type II (SRD5A2) may be associated with benign prostatic …

Abstract Steroid 5-α-reductase type 2 (SRD5a2) is a critical enzyme in androgen
metabolism. Two polymorphisms in the SRD5a2 gene, V89L (rs523349) and A49T …

The crucial role of androgens in the development of prostate cancer is well established. The
aim of this review is to examine the role of constitutional (germline) and tumor-specific …

The identification of common genetic polymorphisms that influence susceptibility to PC
would allow an early risk assessment with earlier and therefore potentially more effective …

To investigate the involvement of the CYP17, SRD5A2, CYP1B1, and CYP2D6 variants with
prostate cancer, a case–control study of 100 patients and an equal number of age-matched …

Prostate cancer is the most commonly diagnosed cancer in men in the United States. It
disproportionately affects African American men when compared to other ethnic groups …