Biocatalysis has undergone revolutionary progress in the past century. Benefited by the
integration of multidisciplinary technologies, natural enzymatic reactions are constantly …

Since the industrial revolution, the rapid growth and development of global industries have
depended largely upon the utilization of coal-derived chemicals, and more recently, the …

Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …

The pharmaceutical industry, driven by an increasing need to deliver new and more effective
medicines to patients, is increasingly turning to the use of engineered biocatalysts for both …

Enzymes are versatile catalysts and their synthetic potential has been recognized for a long
time. In order to exploit their full potential, enzymes often need to be re-engineered or …

Reductions play a key role in organic synthesis, producing chiral products with new
functionalities. Enzymes can catalyse such reactions with exquisite stereo‐, regio‐and …

Substantial improvements in enzyme activity demand multiple mutations at spatially
proximal positions in the active site. Such mutations, however, often exhibit unpredictable …

Recombinant protein production for medical, academic, or industrial applications is essential
for our current life. Recombinant proteins are obtained mainly through microbial …

The ever-growing demand for cost-effective and innocuous biocatalytic transformations has
prompted the rational design and development of robust biocatalytic tools. Enzyme …

Abstract Machine learning as a form of artificial intelligence consists of algorithms and
statistical models for improving computer performance for different tasks. Training data are …