The COVID-19 pandemic is an extraordinary global emergency that has led to the
implementation of unprecedented measures in order to stem the spread of the infection …

Frailty, a consequence of the interaction of the aging process and certain chronic diseases,
compromises functional outcomes in the elderly and substantially increases their risk for …

Functional status is considered the main determinant of healthy aging. Impairment in
skeletal muscle and the cardiovascular system, two interrelated systems, results in …

Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …

Simple Summary Aging and frailty are complex processes implicating multifactorial
mechanisms, which demand for new therapeutic strategies against their devastating effects …

Movement and regular physical activity are two important factors that help the human body
prevent, reduce and treat different chronic diseases such as obesity, type 2 diabetes, heart …

Objectives Regular treadmill exercise may result in changes in pro-inflammatory cytokines
and oxidative stress. However, the way acute treadmill exercise mechanisms affect the …

Free radicals are reactive products that have multiple effects on the human body.
Endogenous and exogenous antioxidants manage the overproduction of free radicals …

Blood vessels are key conduits for the transport of blood and circulating factors.
Abnormalities in blood vessels promote cardiovascular disease (CVD), which has become …

Background Interaction of physical activity and overall immune profile is very complex and
depends on the intensity, duration and frequency of undertaken physical activity, the …