Cutaneous lupus erythematosus: an update on pathogenesis and future therapeutic directions

D Niebel, L de Vos, T Fetter, C Brägelmann… - American Journal of …, 2023 - Springer
Lupus erythematosus comprises a spectrum of autoimmune diseases that may affect various
organs (systemic lupus erythematosus [SLE]) or the skin only (cutaneous lupus …

Systemic lupus erythematosus: one year in review 2023

D Zucchi, E Silvagni, E Elefante, V Signorini… - Clinical and …, 2023 - sfera.unife.it
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of
clinical manifestations and a relapsing-remitting course. New data regarding pathogenic …

Relationship of systemic type I interferon activity with clinical phenotypes, disease activity, and damage accrual in systemic lupus erythematosus in treatment-naive …

K Miyachi, T Iwamoto, S Kojima, T Ida, J Suzuki… - Arthritis Research & …, 2023 - Springer
Background Systemic lupus erythematosus (SLE) is heterogeneous in organ involvement
and disease severity, presenting a broad clinical phenotype. Systemic type I interferon (IFN) …

Plasmacytoid Dendritic Cells Are Not Major Producers of Type 1 IFN in Cutaneous Lupus: An In-Depth Immunoprofile of Subacute and Discoid Lupus

T Vazquez, J Patel, N Kodali, DA Diaz… - Journal of Investigative …, 2024 - Elsevier
The immunologic drivers of cutaneous lupus erythematosus (CLE) and its clinical subtypes
remain poorly understood. We sought to characterize the immune landscape of discoid …

Litifilimab (BIIB059), a promising investigational drug for cutaneous lupus erythematosus

SK Cho, T Vazquez, VP Werth - Expert Opinion on Investigational …, 2023 - Taylor & Francis
Introduction There are no US Food and Drug Administration (FDA) approved therapies for
cutaneous lupus erythematosus (CLE). Litifilimab is a monoclonal antibody against BDCA2 …

Emerging immunotherapeutic strategies for cutaneous lupus erythematosus: an overview of recent phase 2 and 3 clinical trials

D Lim, J Kleitsch, VP Werth - Expert Opinion on Emerging Drugs, 2023 - Taylor & Francis
Introduction Cutaneous lupus erythematosus (CLE) is an autoimmune disease that is
clinically heterogenous and may occur with or without the presence of systemic lupus …

Granzyme serine proteases in inflammation and rheumatic diseases

A Aubert, K Jung, S Hiroyasu, J Pardo… - Nature Reviews …, 2024 - nature.com
Granzymes (granule-secreted enzymes) are a family of serine proteases that have been
viewed as redundant cytotoxic enzymes since their discovery more than 30 years ago …

Modulation of immune cells as a therapy for cutaneous lupus erythematosus

JA Soto, F Melo-González, CA Riedel… - International Journal of …, 2022 - mdpi.com
Cutaneous lupus erythematosus (CLE) is an autoimmune disorder like systemic lupus
erythematosus (SLE). Both SLE and CLE characterize autoantibody secretion and immune …

Recent advances in cutaneous lupus

MP Maz, JWS Martens, A Hannoudi, AL Reddy… - Journal of …, 2022 - Elsevier
Cutaneous lupus erythematosus (CLE) is an inflammatory and autoimmune skin condition
that affects patients with systemic lupus erythematosus (SLE) and exists as an isolated entity …

Comprehensive analysis of cell lineages involved in giant cell arteritis pathogenesis using highly multiplexed imaging mass cytometry

M Robert, LA Chépeaux, Y Glasson… - Autoimmunity …, 2023 - pubmed.ncbi.nlm.nih.gov
Comprehensive analysis of cell lineages involved in giant cell arteritis pathogenesis using
highly multiplexed imaging mass cytometry Comprehensive analysis of cell lineages involved in …