Neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease,
amyotrophic lateral sclerosis, and frontotemporal lobar dementia are among the most …

Although the core concept of remyelination—based on the activation, migration, proliferation
and differentiation of CNS progenitors—has not changed over the past 20 years, our …

The age-related failure to produce oligodendrocytes from oligodendrocyte progenitor cells
(OPCs) is associated with irreversible neurodegeneration in multiple sclerosis (MS) …

One of the most frequent statements, provided in different variations in the introduction of
experimental studies on multiple sclerosis (MS), is that “Multiple sclerosis is a demyelinating …

Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

Demyelination in MS disrupts nerve signals and contributes to axon degeneration. While
remyelination promises to restore lost function, it remains unclear whether remyelination will …

Rapid and efficient protocols to generate oligodendrocytes (OL) from human induced
pluripotent stem cells (iPSC) are currently lacking, but may be a key technology to …

The myelination of axons by oligodendrocytes is a highly complex cell-to-cell interaction.
Oligodendrocytes and axons have a reciprocal signaling relationship in which …

It is widely known that vitamin D receptors have been found in neurons and glial cells, and
their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical …

Background Quantitative in vivo imaging of myelin loss and repair in patients with multiple
sclerosis (MS) is essential to understand the pathogenesis of the disease and to evaluate …