Due to its poor prognosis and propensity for metastasizing, colon cancer, a frequent cancer
of the gastrointestinal system, has a high morbidity and mortality rate. However, the harsh …

Increasing evidence confirmed that the Warburg effect plays an important role involved in
the progression of malignant tumors. Resibufogenin (RES) has been proved to have a …

Lung cancer is one of the most common cancers in the population and is characterized by
non-specific symptoms that delay the diagnosis and reduce the effectiveness of oncological …

Huachansu (HCS) injection has been used for the clinical treatment of hepatocellular
carcinoma (HCC) patients in China for more than thirty years. However, the underlying …

Background Recent studies have shown that bufalin has a good antitumor effect but has
high toxicity, poor water solubility, a short half-life, a narrow therapeutic window, and a toxic …

Cardiotonic steroids (CTS) were first documented by ancient Egyptians more than 3000
years ago. Cardiotonic steroids are a group of steroid hormones that circulate in the blood of …

The main objective of this study was to explore whether autophagy could be triggered by
cinobufagin, and to clarify the role of autophagy in the antitumor effects of cinobufagin on …

A large proportion of cancer patients fail to respond to conventional chemotherapy because
of the intrinsic resistance of their cancer to pro-apoptotic stimuli and/or the acquisition of a …

Chemotherapy-induced peripheral neuropathic pain is a major limiting factor affecting
cancer patients. No effective treatment is currently available. Cinobufacini, an aqueous …

Hepatocellular carcinoma (HCC) is the major type of primary liver cancer and a leading
cause of cancer-related deaths worldwide. Cinobufotalin (CBF) is extracted from the skin …