An integrated strategy to delineate the chemical and dynamic metabolic profile of Huachansu tablets in rat plasma based on UPLC-ESI-QTOF/MSE
Metabolic research is a key method to understand the fate of traditional Chinese medicine
(TCM) prescription in vivo and help to explain its pharmacological effects. Huachansu (HCS) …
(TCM) prescription in vivo and help to explain its pharmacological effects. Huachansu (HCS) …
[HTML][HTML] Cinobufagin-loaded and folic acid-modified polydopamine nanomedicine combined with photothermal therapy for the treatment of lung cancer
J Li, Z Zhang, H Deng, Z Zheng - Frontiers in chemistry, 2021 - frontiersin.org
Cinobufagin is used as a traditional Chinese medicine for cancer therapy. However, it has
some disadvantages, such as poor water solubility, short circulating half-life, and low …
some disadvantages, such as poor water solubility, short circulating half-life, and low …
Toad glandular secretions and skin extractions as anti‐inflammatory and anticancer agents
J Qi, CK Tan, SM Hashimi, AHM Zulfiker… - Evidence‐Based …, 2014 - Wiley Online Library
Toad glandular secretions and skin extractions contain many natural agents which may
provide a unique resource for novel drug development. The dried secretion from the …
provide a unique resource for novel drug development. The dried secretion from the …
[HTML][HTML] Reversal of P-gp-mediated multidrug resistance in colon cancer by cinobufagin
Z Yuan, X Shi, Y Qiu, T Jia, X Yuan… - Oncology …, 2017 - spandidos-publications.com
Cinobufagin (CBF) is isolated from the skin and posterior auricular glands of the Asiatic toad
(Bufo gargarizans). This study investigated the reversal effect of CBF on P-glycoprotein (P …
(Bufo gargarizans). This study investigated the reversal effect of CBF on P-glycoprotein (P …
Cinobufagin inhibits tumor progression and reduces doxorubicin resistance by enhancing FOXO1-mediated transcription of FCGBP in osteosarcoma
X Ma, Z Suo, X Ma, C Zhan, G Luo, J Song - Journal of Ethnopharmacology, 2022 - Elsevier
Abstract Ethnopharmacological relevance Cinobufagin (Huachansu), an aqueous extract
from the dried skin of the toad Bufo bufo gargarizans Cantor (frog skin), is a biologically …
from the dried skin of the toad Bufo bufo gargarizans Cantor (frog skin), is a biologically …
Antiproliferative activity and chemical composition of the venom from the Amazonian toad Rhinella marina (Anura: Bufonidae)
Little is known on the composition of Peruvian Amazon toad venoms. The large toad
Rhinella marina is common in the cleared tropical forests of the Iquitos region and is …
Rhinella marina is common in the cleared tropical forests of the Iquitos region and is …
[HTML][HTML] Bufalin, a component in Chansu, inhibits proliferation and invasion of hepatocellular carcinoma cells
DZ Qiu, ZJ Zhang, WZ Wu, YK Yang - BMC complementary and alternative …, 2013 - Springer
Background Hepatocellular carcinoma (HCC) is a common and aggressive cancer, and the
treatment options are limited for patients with advanced HCC. Bufalin, the major digoxin-like …
treatment options are limited for patients with advanced HCC. Bufalin, the major digoxin-like …
[HTML][HTML] Cultural and medicinal use of amphibians and reptiles by indigenous people in Punjab, Pakistan with comments on conservation implications for …
Simple Summary Humans have interacted with reptile and amphibian species for millennia.
The current study was designed to collect knowledge about the use of amphibian and reptile …
The current study was designed to collect knowledge about the use of amphibian and reptile …
[HTML][HTML] SRC-3 deficiency prevents atherosclerosis development by decreasing endothelial ICAM-1 expression to attenuate macrophage recruitment
W Chen, W Zheng, S Liu, Q Su, K Ding… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Abstract Steroid receptor coactivator 3 (SRC-3) is a member of the p160 SRC family. This
factor can interact with multiple nuclear hormone receptors and transcription factors to …
factor can interact with multiple nuclear hormone receptors and transcription factors to …
[HTML][HTML] Huachansu suppresses human bladder cancer cell growth through the Fas/Fasl and TNF- alpha/TNFR1 pathway in vitro and in vivo
T Yang, R Shi, L Chang, K Tang, K Chen, G Yu… - Journal of Experimental …, 2015 - Springer
Background Huachansu (HCS), a class of toxic steroids extracted from toad venom, which
has been shown to be a valuable anticancer drug in many kinds of cancers. However, the …
has been shown to be a valuable anticancer drug in many kinds of cancers. However, the …